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Maternal exposure to high-fat diet modifies anxiety-like/depression-like behaviors and compounds of Serotonergic System in offspring: A preclinical systematic review.
da Silva, Luana Olegário; da Silva Aragão, Raquel; Duarte Barros, Manuella da Luz; Nogueira Ferraz-Pereira, Kelli; Lins Pinheiro, Isabeli; Galindo, Lígia Cristina Monteiro.
Afiliação
  • da Silva LO; Graduate Program in Nutrition, Physical Activity and Phenotypic Plasticity, Universidade Federal de Pernambuco, Vitória de Santo Antão, Brazil.
  • da Silva Aragão R; Graduate Program in Nutrition, Physical Activity and Phenotypic Plasticity, Universidade Federal de Pernambuco, Vitória de Santo Antão, Brazil.
  • Duarte Barros MDL; Graduate Program in Nutrition, Universidade Federal de Pernambuco, Recife, Brazil.
  • Nogueira Ferraz-Pereira K; Physical Education and Sport Sciences Nucleus, Universidade Federal de Pernambuco, Vitória de Santo Antão, Brazil.
  • Lins Pinheiro I; Unity of Studies in Nutrition and Phenotypic Plasticity, Department of Nutrition, Universidade Federal de Pernambuco, Recife, Brazil.
  • Galindo LCM; Graduate Program in Nutrition, Universidade Federal de Pernambuco, Recife, Brazil.
Int J Dev Neurosci ; 81(5): 371-385, 2021 Aug.
Article em En | MEDLINE | ID: mdl-33788300
Maternal nutrition affects offspring physiology and behavior including susceptibility to mental health-related states. Perinatal high-fat diet (HFD) consumption has been associated with lower levels of serotonin as well as the development of anxiety-like and depression-like behaviors in offspring. The aim of this systematic review was to investigate the effects of maternal HFD during pregnancy and/or lactation on these behaviors and on some aspects of the serotonergic system. Criteria for eligibility included studies of offspring of rodents and non-human primates exposed to HFD at least during pregnancy and/or lactation, offspring that showed outcomes related to anxiety-like and depression-like behaviors and to the serotonergic system. The searches were realized in the LILACS, Web of Science, Scopus, and PubMed databases. The systematic review protocol was registered on the CAMARADES website. The internal validity was assessed by the SYRCLE risk of bias tool. The Kappa index was used for analyzing agreement among the reviewers. In addition, the PRISMA statement was used to report this systematic review. Sixteen articles were included in this review. Most of which studied HFD prior to mating and during pregnancy and lactation. All studies analyzed outcomes related to emotional behavior; three analyzed outcomes related to serotonin system compounds. Maternal consumption of HFD was found to be associated with an inconsistent pattern of the expression of TPH2 as well as reduced the immunoreactivity of 5-HT in the prefrontal cortex and increased 5-HT1A receptor expression in the dorsal raphe of offspring. An association between an HFD and alterations in emotional behavior was found in most of the studies selected.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ansiedade / Serotonina / Exposição Materna / Depressão / Dieta Hiperlipídica Tipo de estudo: Systematic_reviews Limite: Adult / Animals / Female / Humans / Pregnancy Idioma: En Revista: Int J Dev Neurosci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ansiedade / Serotonina / Exposição Materna / Depressão / Dieta Hiperlipídica Tipo de estudo: Systematic_reviews Limite: Adult / Animals / Female / Humans / Pregnancy Idioma: En Revista: Int J Dev Neurosci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos