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Consumption of phenolic-rich jabuticaba (Myrciaria jaboticaba) powder ameliorates obesity-related disorders in mice.
Trindade, Patrícia Leticia; Soares, Elaine Dos Ramos; Inada, Kim Ohanna Pimenta; Martins, Fabiane Ferreira; Rudnicki, Martina; Perrone, Daniel; Monteiro, Mariana; Souza-Mello, Vanessa; Daleprane, Julio Beltrame.
Afiliação
  • Trindade PL; Laboratory for Studies of Interactions between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rua São Francisco Xavier, 524, 112.150 bloco F, 20550-900 Rio de Janeiro, Brazil.
  • Soares EDR; Laboratory for Studies of Interactions between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rua São Francisco Xavier, 524, 112.150 bloco F, 20550-900 Rio de Janeiro, Brazil.
  • Inada KOP; Laboratório de Alimentos Funcionais, Nutrition Institute, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373, CCS, Bloco J, 2° andar, sala 16, 21941-902, Rio de Janeiro, Brazil.
  • Martins FF; Laboratory of Morphometry and Cardiovascular Metabolism, Department of Anatomy, LMMC, Rio de Janeiro State University, Av 28 de Setembro, 87 fds, 20551-030, Rio de Janeiro, Brazil.
  • Rudnicki M; Laboratory for Studies of Interactions between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rua São Francisco Xavier, 524, 112.150 bloco F, 20550-900 Rio de Janeiro, Brazil.
  • Perrone D; Laboratório de Bioquímica Nutricional e de Alimentos, Chemistry Institute, Federal University of Rio de Janeiro, Av. Athos da Silveira Ramos 149, CT, Bloco A, sala 528A, 21941-909, Rio de Janeiro, Brazil.
  • Monteiro M; Laboratório de Alimentos Funcionais, Nutrition Institute, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373, CCS, Bloco J, 2° andar, sala 16, 21941-902, Rio de Janeiro, Brazil.
  • Souza-Mello V; Laboratory of Morphometry and Cardiovascular Metabolism, Department of Anatomy, LMMC, Rio de Janeiro State University, Av 28 de Setembro, 87 fds, 20551-030, Rio de Janeiro, Brazil.
  • Daleprane JB; Laboratory for Studies of Interactions between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rua São Francisco Xavier, 524, 112.150 bloco F, 20550-900 Rio de Janeiro, Brazil.
Br J Nutr ; 127(3): 344-352, 2022 02 14.
Article em En | MEDLINE | ID: mdl-33787474
Accumulating evidence indicates that dietary phenolic compounds can prevent obesity-related disorders. We investigated whether the consumption of polyphenol-rich jabuticaba peel and seed powder (JPSP) could ameliorate the progression of diet-induced obesity in mice. Male mice were fed a control diet or a high-fat (HF) diet for 9 weeks. After this period, mice were fed control, HF or HF diets supplemented with 5 % (HF-J5), 10 % (HF-J10) or 15 % (HF-J15) of JPSP, for 4 additional weeks. Supplementation with JPSP not only attenuated HF-induced weight gain and fat accumulation but also ameliorated the pro-inflammatory response associated with obesity, as evidenced by the absence of mast cells in the visceral depot accompanied by lower IL-6 and TNF-α at the tissue and circulating levels. JPSP-supplemented mice also exhibited smaller-sized adipocytes, reduced levels of leptin and higher levels of adiponectin, concomitant with improved glucose metabolism and insulin sensitivity. The magnitude of the observed effects was dependent on JPSP concentration with HF-J10- and HF-J15-fed mice showing metabolic profiles similar to control. This study reveals that the consumption of JPSP protects against the dysfunction of the adipose tissue and metabolic disturbances in obese mice. Thus, these findings indicate the therapeutic potential of the phenolic-rich JPSP in preventing obesity-related disorders.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dieta Hiperlipídica / Obesidade Limite: Animals Idioma: En Revista: Br J Nutr Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dieta Hiperlipídica / Obesidade Limite: Animals Idioma: En Revista: Br J Nutr Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido