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Exceptional T CD4+ Recovery Post-antiretroviral Is Linked to a Lower HIV Reservoir with a Specific Immune Differentiation Pattern.
Rodríguez-Castañón, José Miguel; Mcnaughton, Andrew; Cárdenas-Ochoa, Ayleen; Fuentes-Romero, Luis León; Viveros-Rogel, Mónica; Vergara-Mendoza, Moisés; Tello-Mercado, Andrea C; Leal-Gutiérrez, Graciela; Romero-Carvajal, Juan José; Cázares-Lara, Jonnathan; Camiro-Zúñiga, Antonio; Jaramillo-Jante, Rocío; Antuna-Puente, Barbara; Galindo-Fraga, Arturo; Soto-Ramírez, Luis E; Sierra-Madero, Juan G; Perez-Patrigeon, Santiago.
Afiliação
  • Rodríguez-Castañón JM; Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición salvador Zubirán, Mexico City, Mexico.
  • Mcnaughton A; Division of Infectious Diseases, Queen's University, Kingston, Canada Kingston, Canada.
  • Cárdenas-Ochoa A; Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición salvador Zubirán, Mexico City, Mexico.
  • Fuentes-Romero LL; Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición salvador Zubirán, Mexico City, Mexico.
  • Viveros-Rogel M; Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición salvador Zubirán, Mexico City, Mexico.
  • Vergara-Mendoza M; Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición salvador Zubirán, Mexico City, Mexico.
  • Tello-Mercado AC; Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición salvador Zubirán, Mexico City, Mexico.
  • Leal-Gutiérrez G; Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición salvador Zubirán, Mexico City, Mexico.
  • Romero-Carvajal JJ; Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición salvador Zubirán, Mexico City, Mexico.
  • Cázares-Lara J; Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición salvador Zubirán, Mexico City, Mexico.
  • Camiro-Zúñiga A; Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición salvador Zubirán, Mexico City, Mexico.
  • Jaramillo-Jante R; Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición salvador Zubirán, Mexico City, Mexico.
  • Antuna-Puente B; Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
  • Galindo-Fraga A; Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición salvador Zubirán, Mexico City, Mexico.
  • Soto-Ramírez LE; Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición salvador Zubirán, Mexico City, Mexico.
  • Sierra-Madero JG; Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición salvador Zubirán, Mexico City, Mexico.
  • Perez-Patrigeon S; Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición salvador Zubirán, Mexico City, Mexico.
AIDS Res Hum Retroviruses ; 38(1): 11-21, 2022 01.
Article em En | MEDLINE | ID: mdl-33779241
We present a cohort of individuals who reached CD4+ T cell counts of greater than 1,000 cells/mm3 (Hypers) after starting antiretroviral treatment (ART) and compared them with those who reached between 350 and 999 CD4+ T cells/mm3 (Concordants). Demographic data, immune recovery kinetics, T CD4+ subset phenotypes, and integrated HIV DNA were analyzed. Data from individuals living with HIV on their first ART regimen and after 48 months of follow-up were obtained. Immune phenotype by Flow Cytometry analysis on whole blood was performed, cytokines were measured, and integrated HIV-1 DNA was measured by polymerase chain reaction. From a total of 424 individuals, 26 Hypers (6.1%), 314 Concordants (74.1%), and 84 (19.8%) discordants were identified. Hypers had a higher proportion of CD4+-naive (Nv) T cells (37.6 vs. 24.8, p < .05), and a low proportion of CD4+ effector memory T cells (27.9 vs. 39.4, p < .05), with similar results found in CD8+ T cells. Hypers demonstrated a higher percentage of CD4+CD45RA+CD31neg cells with a lower response to interleukin-2 stimulation and a lower integrated HIV-1 DNA/CD4 ratio (1.2 vs. 2.89, p < .05). In Hypers, T cell recovery occurs very early after initiation of ART. Following this initial recovery state, their CD4+ T cell level homeostasis seems to be driven by nonthymic-central-Nv cells. This exceptional recovery is associated with a lower HIV reservoir, which may be related to an increase in noninfected CD4+ T cells. These patients could then be eligible candidates for cure trials.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Linfócitos T CD8-Positivos Limite: Humans Idioma: En Revista: AIDS Res Hum Retroviruses Assunto da revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Linfócitos T CD8-Positivos Limite: Humans Idioma: En Revista: AIDS Res Hum Retroviruses Assunto da revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos