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The Relationship of Circulating Homocysteine with Fibrinogen, Blood Pressure, and Other Cardiovascular Measures in African Adolescents.
du Plessis, Jacomina P; Nienaber-Rousseau, Cornelie; Lammertyn, Leandi; Schutte, Aletta E; Pieters, Marlien; Kruger, Herculina S.
Afiliação
  • du Plessis JP; Center of Excellence for Nutrition, North-West University, Potchefstroom, South Africa.
  • Nienaber-Rousseau C; Center of Excellence for Nutrition, North-West University, Potchefstroom, South Africa; Hypertension in Africa Research Team, North-West University, Potchefstroom, South Africa. Electronic address: cornelie.nienaber@nwu.ac.za.
  • Lammertyn L; Hypertension in Africa Research Team, North-West University, Potchefstroom, South Africa; Medical Research Council Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa.
  • Schutte AE; Hypertension in Africa Research Team, North-West University, Potchefstroom, South Africa; Medical Research Council Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa; School of Population Health, University of New South Wales, The George Institute fo
  • Pieters M; Center of Excellence for Nutrition, North-West University, Potchefstroom, South Africa; Hypertension in Africa Research Team, North-West University, Potchefstroom, South Africa.
  • Kruger HS; Center of Excellence for Nutrition, North-West University, Potchefstroom, South Africa; Hypertension in Africa Research Team, North-West University, Potchefstroom, South Africa.
J Pediatr ; 234: 158-163.e2, 2021 Jul.
Article em En | MEDLINE | ID: mdl-33775664
OBJECTIVES: To evaluate the associations between homocysteine (Hcy) and cardiovascular health in South African adolescents. STUDY DESIGN: Circulating Hcy concentrations of 172 South African adolescents (105 girls, ages 13 to <18 years) were measured. Anthropometric and cardiovascular factors were also included and cross-sectionally analyzed through general linear models. RESULTS: Hcy correlated positively with body weight (P = .03; after adjusting for multiple testing, it was not regarded as significant) and muscle mass (P = .01), but negatively with fibrinogen concentrations (P = .001). Across Hcy tertiles, blood pressure produced approximating U-shaped curves, with differences between the middle and upper tertiles (all P < .02). Forty percent of the adolescents had elevated blood pressure, of whom 37% fell in the lowest and 38% in the highest Hcy tertiles. Hcy differed between the sexes (with boys having higher Hcy), but not between subgroups based on puberty, weight, stunting, smoking, or alcohol consumption. CONCLUSIONS: Both high and low Hcy could be early contributing risk factors to cardiovascular health. The associations between Hcy and blood pressure suggest that dietary and lifestyle manipulation, to achieve the optimal range of Hcy, may be beneficial in preventing Hcy-related hypertension in adulthood. The inverse relationship between Hcy and fibrinogen remains to be clarified.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Risco de Doenças Cardíacas / Homocisteína Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Female / Humans / Male País/Região como assunto: Africa Idioma: En Revista: J Pediatr Ano de publicação: 2021 Tipo de documento: Article País de afiliação: África do Sul País de publicação: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Risco de Doenças Cardíacas / Homocisteína Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Female / Humans / Male País/Região como assunto: Africa Idioma: En Revista: J Pediatr Ano de publicação: 2021 Tipo de documento: Article País de afiliação: África do Sul País de publicação: Estados Unidos