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Prescription of statins and pharmacokinetic interactions in Colombian patients.
Valladales-Restrepo, Luis Fernando; Medina-Morales, Diego Alejandro; Giraldo-Giraldo, Claudia; Machado-Alba, Jorge Enrique.
Afiliação
  • Valladales-Restrepo LF; Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A, Pereira, Risaralda, Colombia.
  • Medina-Morales DA; Grupo De Investigación Biomedicina, Facultad de Medicina, Fundación Universitaria Autónoma de las Américas, Pereira, Colombia.
  • Giraldo-Giraldo C; Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A, Pereira, Risaralda, Colombia.
  • Machado-Alba JE; Grupo De Investigación Biomedicina, Facultad de Medicina, Fundación Universitaria Autónoma de las Américas, Pereira, Colombia.
Expert Opin Drug Metab Toxicol ; 17(5): 627-634, 2021 May.
Article em En | MEDLINE | ID: mdl-33759676
Background: Statins have extensive hepatic metabolism and can have multiple pharmacological interactions. The aim was to identify the main pharmacokinetic interactions between statins and their comedications in a group of patients from Colombia.Research design and methods: A cross-sectional study of pharmacokinetic interactions in patients treated with statins who were identified from a population database. The interactions were documented using the Lexicomp® database.Results: A total of 123,026 patients with statin prescriptions were identified, with a mean age of 68.4 ± 11.5 years; 57.1% were women, and 81.6% received atorvastatin. A total of 19.4% (n = 23.831) of patients presented pharmacological interactions. Some 15,474 (12.6%) had interactions classified as category C, 7.4% (n = 9077) as category D, and 0.5% (n = 660) as category X. 36.8% of the patients with lovastatin prescriptions had some interaction. Age older than 65 years, male sex, residence in capital cities, comorbidities, endocrine pathologies and HIV were associated with an increase in the probability of having contraindicated or risky interactions.Conclusions: Important interactions between statins and other medications were more common in adults over 65 years of age and those with endocrine comorbidities or HIV infection. This knowledge should help when proposing solutions that reduce the risk of adverse reactions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lovastatina / Inibidores de Hidroximetilglutaril-CoA Redutases / Atorvastatina Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Colombia Idioma: En Revista: Expert Opin Drug Metab Toxicol Assunto da revista: METABOLISMO / TOXICOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lovastatina / Inibidores de Hidroximetilglutaril-CoA Redutases / Atorvastatina Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Colombia Idioma: En Revista: Expert Opin Drug Metab Toxicol Assunto da revista: METABOLISMO / TOXICOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Reino Unido