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Multiple clades of Husavirus in South America revealed by next generation sequencing.
Ramos, Endrya do Socorro Fôro; Rosa, Ulisses Alves; Ribeiro, Geovani de Oliveira; Villanova, Fabiola; Milagres, Flávio Augusto de Pádua; Brustulin, Rafael; Morais, Vanessa Dos Santos; Araújo, Emerson Luiz Lima; Pandey, Ramendra Pati; Raj, V Samuel; Sabino, Ester Cerdeira; Deng, Xutao; Delwart, Eric; Luchs, Adriana; Leal, Élcio; da Costa, Antonio Charlys.
Afiliação
  • Ramos EDSF; Laboratório de Diversidade Viral, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Rosa UA; Laboratório de Diversidade Viral, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Ribeiro GO; Laboratório de Diversidade Viral, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Villanova F; Laboratório de Diversidade Viral, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Milagres FAP; Secretary of Health of Tocantins, Tocantins, Brazil.
  • Brustulin R; Public Health Laboratory of Tocantins State (LACEN/TO), Tocantins, Brazil.
  • Morais VDS; Secretary of Health of Tocantins, Tocantins, Brazil.
  • Araújo ELL; Public Health Laboratory of Tocantins State (LACEN/TO), Tocantins, Brazil.
  • Pandey RP; Departamento de Moléstias Infecciosas e Parasitárias, Instituto de Medicina Tropical da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Raj VS; General Coordination of Public Health Laboratories of the Strategic Articulation, Department of the Health Surveillance Secretariat of the Ministry of Health (CGLAB/DAEVS/SVS-MS), Brasília, Federal District, Brazil.
  • Sabino EC; Centre for Drug Design Discovery and Development (C4D), SRM University, Delhi-NCR, Rajiv Gandhi Education City, Sonepat, Haryana, India.
  • Deng X; Centre for Drug Design Discovery and Development (C4D), SRM University, Delhi-NCR, Rajiv Gandhi Education City, Sonepat, Haryana, India.
  • Delwart E; Departamento de Moléstias Infecciosas e Parasitárias, Instituto de Medicina Tropical da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Luchs A; Vitalant Research Institute, San Francisco, California, United States of America.
  • Leal É; Department Laboratory Medicine, University of California San Francisco, San Francisco, California, United States of America.
  • da Costa AC; Vitalant Research Institute, San Francisco, California, United States of America.
PLoS One ; 16(3): e0248486, 2021.
Article em En | MEDLINE | ID: mdl-33755700
Husavirus (HuV) is an unclassified virus of the order Picornavirales that has already been identified worldwide in various locations. The genetic, epidemiological, and pathogenic characteristics are, however, little understood. In children with acute gastroenteritis, this study used next-generation sequencing to recognize unknown sources of viruses. In particular, 251 fecal samples obtained from individuals were sequenced in southern, northeastern, and northern Brazil. all samples were also analyzed using culture methods and parasitological tests to classify other enteric pathogens such as bacteria, parasites, and viruses. 1.9% of the samples tested positive for HuV, for a total of 5 positive children, with a mean age of 2 year, with three males and two females. Detailed molecular characterization of full genomes showed that Brazilian HuVs' nucleotide divergence is less than 11%. The genetic gap between Brazilian sequences and the closest HuV reported previously, on the other hand, is 18%. The study showed that Brazilian sequences are closely related to the HuV defined in Viet Nam in 2013, further characterization based on phylogenetics. At least two divergent clades of HuV in South America were also seen in the phylogenetic study.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genoma Viral / Infecções por Picornaviridae / Vírus de RNA de Cadeia Positiva Tipo de estudo: Prognostic_studies Limite: Child, preschool / Female / Humans / Infant / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genoma Viral / Infecções por Picornaviridae / Vírus de RNA de Cadeia Positiva Tipo de estudo: Prognostic_studies Limite: Child, preschool / Female / Humans / Infant / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos