Oxysterols and mesenchymal stem cell biology.

Reichert, Cadiele Oliana; de Freitas, Fabio Alessandro; Levy, Débora; Bydlowski, Sérgio Paulo

Reichert, Cadiele Oliana; de Freitas, Fabio Alessandro; Levy, Débora; Bydlowski, Sérgio Paulo.

Afiliação

Reichert CO; Lipids, Oxidation and Cell Biology Team, Laboratory of Immunology (LIM19), Heart Institute (InCor), School of Medicine, University of São Paulo, São Paulo, Brazil.
de Freitas FA; Lipids, Oxidation and Cell Biology Team, Laboratory of Immunology (LIM19), Heart Institute (InCor), School of Medicine, University of São Paulo, São Paulo, Brazil.
Levy D; Lipids, Oxidation and Cell Biology Team, Laboratory of Immunology (LIM19), Heart Institute (InCor), School of Medicine, University of São Paulo, São Paulo, Brazil.
Bydlowski SP; Lipids, Oxidation and Cell Biology Team, Laboratory of Immunology (LIM19), Heart Institute (InCor), School of Medicine, University of São Paulo, São Paulo, Brazil. Electronic address: spbydlow@usp.br.

Vitam Horm ; 116: 409-436, 2021.

Article em En | MEDLINE | ID: mdl-33752827

RESUMO

Mesenchymal stem cells have the ability to differentiate into several cell types when exposed to determined substances, including oxysterols. Oxysterols are cholesterol products derived from its auto-oxidation by reactive species or from enzymatic action. They are present in the body in low quantities under physiological conditions and exhibit several physiological and pharmacological actions according to both the types of oxysterol and tissue. Some of them are cytotoxic while others have been shown to promote cell differentiation through the action on several different receptors, such as nuclear LXR receptors and Smoothened receptor ligands. Here, we review the main pathways by which oxysterols have been associated with cell differentiation and death of mesenchymal stem cells.

Assuntos

Células-Tronco Mesenquimais; Oxisteróis; Diferenciação Celular; Humanos; Células-Tronco Mesenquimais/citologia; Oxisteróis/farmacologia

Palavras-chave

Apoptosis; Autophagy; Cell death; Cell differentiation; Mesenchymal stem cell; Oxysterol

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Mesenquimais / Oxisteróis Limite: Humans Idioma: En Revista: Vitam Horm Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

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