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Genetic variations in the human immune system influence susceptibility to tegumentary leishmaniasis: a systematic review and meta-analysis.
Lera-Nonose, Daniele Stéfanie Sara Lopes; De Oliveira, Larissa Ferreira; Brustolin, Aline; Santos, Thais Silva; Oyama, Jully; Ramos-Milaré, Áquila Carolina Fernandes Herculano; Terron-Monich, Mariana De Souza; Demarchi, Izabel Galhardo; Neto, Quirino Alves De Lima; Teixeira, Jorge Juarez Vieira; Lonardoni, Maria Valdrinez Campana.
Afiliação
  • Lera-Nonose DSSL; Graduate Program in Health Sciences, Universidade Estadual De Maringá, Maringá, Paraná, Brazil.
  • De Oliveira LF; Department of Clinical Analysis and Biomedicine- Laboratory of Leishmaniasis, Universidade Estadual De Maringá, Maringá, Paraná, Brazil.
  • Brustolin A; Undergraduate Student in Biomedicine Degree, Universidade Estadual De Maringá, Maringá, Paraná, Brazil.
  • Santos TS; Graduate Program in Health Sciences, Universidade Estadual De Maringá, Maringá, Paraná, Brazil.
  • Oyama J; Graduate Program in Bioscience and Physiopathology, Universidade Estadual De Maringá, Maringá, Paraná, Brazil.
  • Ramos-Milaré ÁCFH; Graduate Program in Bioscience and Physiopathology, Universidade Estadual De Maringá, Maringá, Paraná, Brazil.
  • Terron-Monich MS; Graduate Program in Health Sciences, Universidade Estadual De Maringá, Maringá, Paraná, Brazil.
  • Demarchi IG; Department of Clinical Analysis and Biomedicine- Laboratory of Leishmaniasis, Universidade Estadual De Maringá, Maringá, Paraná, Brazil.
  • Neto QAL; Graduate Program in Health Sciences, Universidade Estadual De Maringá, Maringá, Paraná, Brazil.
  • Teixeira JJV; Department of Basic Science-Laboratory of Immunogenetics, Universidade Estadual De Maringá, Maringá, Paraná, Brazil.
  • Lonardoni MVC; Graduate Program in Health Sciences, Universidade Estadual De Maringá, Maringá, Paraná, Brazil.
Expert Rev Clin Immunol ; 17(5): 513-537, 2021 05.
Article em En | MEDLINE | ID: mdl-33749481
OBJECTIVES: The outcomes of tegumentary leishmaniasis (TL) rely on a complex interaction between the host immune system and the parasite. This study assessed the influence of polymorphisms in immune-related genes on TL. METHODS: Web of Science, Scopus, PubMed, and Embase databases were searched systemically. The meta-analysis used a retrospective model in examining alleles, heterozygotes, and homozygotes. A quality assessment and an analysis of cumulative evidence were performed. RESULTS: A total of 29 genes (encoding for cytokines, chemokines, and other immune receptors) and 84 polymorphisms were analyzed. The IL-1ß_rs16944 (OR = 1.341, p = 0.003), TNF-α_rs1800629 (OR = 3.804, p = 0.004), MIF_rs755622 (OR = 3.357, p = 0.001), and INF- γ_rs243056 (OR = 1.670, p = 0.028) polymorphisms were speculated as risk factor for TL. They decrease the expression of the corresponding genes crucial for TL control. The quality assessment score was approximately 50%, suggesting the need for a clear method and polymorphism characterization for further comparison. The relevant risk of bias and other considerations resulted in low and moderate cumulative evidence confidence. CONCLUSIONS: IL-1ß_rs16944, TNF-α_rs1800629, MIF_rs755622, and INF-γ_rs2430561 polymorphisms were speculated as risk factor for TL, corroborating that IL-1ß, TNF-α, INF-γ, and MIF are involved in the TL pathogenesis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leishmaniose / Predisposição Genética para Doença / Sistema Imunitário Tipo de estudo: Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Expert Rev Clin Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leishmaniose / Predisposição Genética para Doença / Sistema Imunitário Tipo de estudo: Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Expert Rev Clin Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido