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Ectyoplasin, a novel cytotoxic cyclic peptide from Ectyoplasia ferox sponge.
Ortiz-Celiseo, Araceli; Valerio-Alfaro, Gerardo; Sosa-Rueda, Javier; López-Fentanes, Fernando C; Domínguez-Melendez, Vanihamin; Cen-Pacheco, Francisco.
Afiliação
  • Ortiz-Celiseo A; Faculty of Bioanalysis, Veracruz University, Veracruz, Mexico.
  • Valerio-Alfaro G; Food Research and Development Unit, Technological Institute of Veracruz, Veracruz, Mexico.
  • Sosa-Rueda J; Food Research and Development Unit, Technological Institute of Veracruz, Veracruz, Mexico.
  • López-Fentanes FC; Faculty of Bioanalysis, Veracruz University, Veracruz, Mexico.
  • Domínguez-Melendez V; Faculty of Medicine Veterinary and Zootechnics, Veracruz University, Veracruz, Mexico.
  • Cen-Pacheco F; Faculty of Bioanalysis, Veracruz University, Veracruz, Mexico.
Nat Prod Res ; 36(15): 3957-3964, 2022 Aug.
Article em En | MEDLINE | ID: mdl-33749445
A new cyclic heptapeptide, ectyoplasin (1), was isolated from a methanol extract of the sponge Ectyoplasia ferox. The planar structure of 1, cyclo(-Leu1-Asn2-Ala3-Val4-Thr5-Pro6-Gly7-), was determined by one and two-dimensional NMR spectroscopy and high-resolution tandem mass spectrometry. Its absolute stereochemistry was solved by Marfey's method. The in vitro assays show that ectyoplasin (1) possess significant cytotoxic activity (2.9 - 23.5 µM) against the cell lines, DU-145 (human prostate cancer), Jurkat (human T-cell acute leukaemia), MM144 (human multiple myeloma), HeLa (human cervical carcinoma) and CADO-ES1 (human Ewing's sarcoma). The DU-145 cell line showed apoptotic cell death in response to ectyoplasin (1) treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poríferos / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Nat Prod Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poríferos / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Nat Prod Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido