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Association of FSHR, LH, LHR, BMP15, GDF9, AMH, and AMHR polymorphisms with poor ovarian response in patients undergoing in vitro fertilization.
Meireles, Arivaldo José Conceição; Bilibio, João Paolo; Lorenzzoni, Pânila Longhi; Conto, Emily De; Nascimento, Fábio Costa do; Cunha-Filho, João Sabino da.
Afiliação
  • Meireles AJC; Clinica Pronatus Centro de Reprodução Humana, Belém, Pará, Brazil.
  • Bilibio JP; Programa de Pós Graduação de Ciências Médicas da Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
  • Lorenzzoni PL; Clinica Pronatus Centro de Reprodução Humana, Belém, Pará, Brazil.
  • Conto E; Department of Obstetrics and Gynecology, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Nascimento FCD; Clinica Pronatus Centro de Reprodução Humana, Belém, Pará, Brazil.
  • Cunha-Filho JSD; Programa de Pós Graduação de Ciências Médicas da Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
JBRA Assist Reprod ; 25(3): 439-446, 2021 07 21.
Article em En | MEDLINE | ID: mdl-33739800
OBJECTIVE: This paper aimed to assess the correlation between LH, LHR, GDF9, FSHR, AMH, AMHR2, and BMP15 polymorphisms, which are related to follicular development, and decreased ovarian response in women undergoing controlled ovarian hyperstimulation (COH) for IVF. METHODS: This age-matched case-control study included three or four controls per woman undergoing COH. Controls were women with normal ovarian response (NOR) and cases were women with poor ovarian response (POR) in oocyte retrieval (three or fewer oocytes). DNA was extracted from peripheral blood and potential associations with gene polymorphisms related to follicular development (LH, LHR, GDF9, FSHR, AMH, AMHR2, and BMP15) were analyzed. RESULTS: Sixty-six patients were included, 52 in the NOR and 14 in the POR group. Two GDF9 polymorphisms were associated with follicular response after COH, one associated with POR - the presence of a mutant polymorphism in heterozygosis and homozygosis of the GDF9 398-39 (C to G) [23% NOR versus 68% POR (OR 4.01, CI 1.52-10.6, p=0.005)] - and another associated with protective response - the presence of normal homozygosis of GDF9 (C447T) [19.2% NOR versus 50% POR (OR 0.34, IC 0.14-0.84, p=0.019)]. No additional associations were found between the other analyzed polymorphisms and POR. CONCLUSIONS: This study found that GDF9 appears to play an important role in follicular development, whereas polymorphisms in its DNA chain may negatively affect ovarian reserve, such as 398-39 (C to G), or positively, as seen in C447T.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fertilização in vitro / Reserva Ovariana Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: JBRA Assist Reprod Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fertilização in vitro / Reserva Ovariana Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: JBRA Assist Reprod Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil