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Long-term ecotoxicological effects of ciprofloxacin in combination with caffeine on the microalga Raphidocelis subcapitata.
Diniz, Vinicius; Rath, Gabriela; Rath, Susanne; Rodrigues-Silva, Caio; Guimarães, José R; Cunha, Davi G F.
Afiliação
  • Diniz V; Department of Infrastructure and Environment, School of Civil Engineering, Architecture and Urban Design, University of Campinas, Campinas, Brazil.
  • Rath G; Institute of Chemistry, University of Campinas, Campinas, Brazil.
  • Rath S; Department of Hydraulics and Sanitation, São Carlos School of Engineering, University of São Paulo, São Carlos, Brazil.
  • Rodrigues-Silva C; Institute of Chemistry, University of Campinas, Campinas, Brazil.
  • Guimarães JR; Institute of Chemistry, University of Campinas, Campinas, Brazil.
  • Cunha DGF; Institute of Chemistry, University of Campinas, Campinas, Brazil.
Toxicol Rep ; 8: 429-435, 2021.
Article em En | MEDLINE | ID: mdl-33717995
Ciprofloxacin (CIP) is an antimicrobial "pseudo-persistent" in aquatic ecosystems. Once dispersed in the water compartments, it can also affect the microalgae. Thus, the evaluation of its long-term ecotoxicological effects is necessary. CIP interactions with other pharmaceuticals are not well known. In this study, we investigated the toxic effects of CIP alone and combined with caffeine (CAF), using the modified Gompertz model parameters and the chlorophyll-a production of the microalga Raphidocelis subcapitata as endpoints, throughout a 16-day exposure assay. The exposure to CIP alone led to significant reductions of the growth rate and the cell density of the microalgae compared to control groups. The combination with CAF lowered the adverse effects of CIP to R. subcapitata. However, as the toxicity is dynamic, our results indicated that the toxic effects in respect to the studied endpoints changed throughout the exposure period, reinforcing the need for longer-term ecotoxicity assessments.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Toxicol Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Toxicol Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda