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EWSR1-ATF1 Fusion in a Myoepithelial Carcinoma of Soft Tissue With Small Round Cell Morphology: A Potential Diagnostic Pitfall.
Leckey, Bruce D; John, Ivy; Reyes-Múgica, Miguel; Naous, Rana.
Afiliação
  • Leckey BD; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA.
  • John I; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA.
  • Reyes-Múgica M; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA.
  • Naous R; Department of Pathology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA.
Pediatr Dev Pathol ; 24(3): 258-263, 2021.
Article em En | MEDLINE | ID: mdl-33683984
Myoepithelial tumors of soft tissue are rare mesenchymal neoplasms that overlap with their salivary gland and skin counterparts at both the histopathologic and molecular levels. EWSR1 gene rearrangements with various fusion partners represent a common genetic event in myoepithelial tumors of soft tissue, whether benign or malignant, and may prove useful as a diagnostic tool in difficult cases. However, the number of diagnostic entities with EWSR1 gene rearrangements has grown considerably in recent years, and there is significant morphologic and immunophenotypic overlap amongst this group, underscoring the importance of fusion testing to detect fusion partners that are characteristic of discrete diagnostic entities. Herein, we report a malignant myoepithelial tumor of soft tissue/myoepithelial carcinoma with an undifferentiated round cell morphology arising in a pediatric patient with a EWSR1-ATF1 gene fusion.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias de Tecidos Moles / Proteínas de Fusão Oncogênica / Carcinoma de Células Pequenas / Mioepitelioma Tipo de estudo: Diagnostic_studies Limite: Adolescent / Humans / Male Idioma: En Revista: Pediatr Dev Pathol Assunto da revista: PATOLOGIA / PEDIATRIA Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias de Tecidos Moles / Proteínas de Fusão Oncogênica / Carcinoma de Células Pequenas / Mioepitelioma Tipo de estudo: Diagnostic_studies Limite: Adolescent / Humans / Male Idioma: En Revista: Pediatr Dev Pathol Assunto da revista: PATOLOGIA / PEDIATRIA Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos