Threedimensional models to study breast cancer (Review).
Int J Oncol
; 58(3): 331-343, 2021 03.
Article
em En
| MEDLINE
| ID: mdl-33650654
Breast cancer (BC) is the most commonly occurring cancer and primary cause of cancerrelated mortality in women worldwide. Investigations into BC have been conducted in in vitro and in vivo models. Of these models, the cultivation of tumor cell lines in twodimensional models is the most widely employed in vitro model to study tumor physiology. However, this approach does not accurately model all aspects observed in tumors. To address these limitations, threedimensional (3D) in vitro models have been developed. In these, it is possible to reproduce the interaction between tumor cells and the extracellular matrix, as well as the interrelationship between tumor cells and stromal cells, in order to replicate the interactions observed within the 3D environment of in vivo tumors. The present review summarizes the most common 3D in vitro models used to study BC, including spheroid models, organonachip models, hydrogel models and bioprinted models, with a discussion of their particular advantages and limitations.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Esferoides Celulares
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Dispositivos Lab-On-A-Chip
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Bioimpressão
Limite:
Female
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Humans
Idioma:
En
Revista:
Int J Oncol
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
Grécia