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Evaluation of a strategy for identification of hepatitis C virus carriers in outpatient and emergency units: contribution to the microelimination of hepatitis C in Brazil.
Gardona, Rodrigo; Appel, Flavia; Ercolin, Samara; Carvalho-Filho, Roberto J; Barbosa, Dulce A; Ferraz, Maria Lucia.
Afiliação
  • Gardona R; Universidade Federal de São Paulo, Disciplina de Gastroenterologia, São Paulo, SP, Brazil.
  • Appel F; Universidade Federal de São Paulo, Disciplina de Gastroenterologia, São Paulo, SP, Brazil.
  • Ercolin S; Universidade Federal de São Paulo, Disciplina de Gastroenterologia, São Paulo, SP, Brazil.
  • Carvalho-Filho RJ; Universidade Federal de São Paulo, Disciplina de Gastroenterologia, São Paulo, SP, Brazil.
  • Barbosa DA; Universidade Federal de São Paulo, Escola Paulista de Enfermagem, São Paulo, SP, Brazil.
  • Ferraz ML; Universidade Federal de São Paulo, Disciplina de Gastroenterologia, São Paulo, SP, Brazil. Electronic address: marialucia.ferraz@uol.com.br.
Braz J Infect Dis ; 25(2): 101546, 2021.
Article em En | MEDLINE | ID: mdl-33636108
INTRODUCTION: Hepatitis C virus (HCV) infection continues to be an important public health problem worldwide. Despite the availability of drugs that promote the cure of infection in more than 95% of cases, the identification of HCV carriers remains a major challenge. OBJECTIVE: To evaluate a strategy for identifying HCV carriers based on combined criteria: screening in emergency units and specialty outpatient clinics of a tertiary hospital and among older adults (≥45 years), both suggested as efficient in epidemiological studies. METHODS: A cross-sectional, analytical and descriptive study was conducted on individuals of both sexes, aged 45 years and older, attending the emergency department and specialty outpatient clinics of a University Hospital in São Paulo, Brazil, from January 2016 to June 2018. After giving formal consent, the patients were submitted to a standardized interview and rapid testing for the identification of HCV antibodies (SD BIOLINE® anti-HCV). RESULTS: A total of 606 adult patients (62% women and 37% men) were evaluated. The mean age was 62±10 years. Four positive tests were identified, with confirmation by conventional serology and HCV-RNA determination. Thus, the prevalence of HCV identified in the sample was 0.66%. All patients had a history of risk factors for infection. CONCLUSION: The strategies of birth-cohort testing and screening in emergency medical services for the identification of HCV carries, both suggested in the literature as efficient for the diagnosis of hepatitis C, resulted in a low rate of HCV infection. These findings highlight the magnitude of the challenge of identifying asymptomatic HCV carriers in Brazil.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatite C / Hepacivirus Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Braz J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatite C / Hepacivirus Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Braz J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil