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Devitalized Autograft Associated with the Vascularized Fibula Graft: Irradiation versus Freezing Methods.
Rezende, Luis Guilherme Rosifini Alves; Margatho, Guilherme Leipner; Penno, Ricardo Alberto Lupinacci; Mazzer, Nilton; Engel, Edgard Eduard.
Afiliação
  • Rezende LGRA; Hand Division of Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil.
  • Margatho GL; Orthopedic Resident of Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil.
  • Penno RAL; Hand Division of Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil.
  • Mazzer N; Hand Division of Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil.
  • Engel EE; Orthopedic Oncologic Division of Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil.
J Reconstr Microsurg ; 37(8): 655-661, 2021 Oct.
Article em En | MEDLINE | ID: mdl-33634442
BACKGROUND: Among the alternatives for the management of malignant bone tumors is the "devitalized autograft associated with vascularized fibula graft." The devitalization process is achieved by pasteurization, irradiation, or freezing. The combination of these grafts has been broadly researched for more than 25 years. However, there is no research currently published comparing the various methods or their respective outcomes. METHODS: A retrospective study was compiled of 26 devitalized autografts associated with vascularized fibula performed to limb salvage of malignant bone tumors. They were divided into two groups according to the devitalization method: either freezing (12 procedures) or irradiation (14 procedures). Clinical, radiographic, and scintigraphic results were assessed at least 24 months after surgery. RESULTS: The union rates reached 83.3% in the freezing group and 92.8% in the irradiated group but did not express different outcomes. Scintigraphic viability was observed in all the grafts that achieved radiographic union (Mann-Whitney U-test: p = 0.005). Three patients had nonunion, with only one having no viability in the scintigraphy (Mann-Whitney U-test: p = 0.001). There was no malignant recurrence in the autograft, only in surrounding soft tissues. Local recurrence was statistically higher in larger tumors (Mann-Whitney U-test: p = 0.025). CONCLUSION: Both groups presented similar union rates and are considered safe to devitalize bone graft despite different outcomes observed. The survivor rates observed could be limited by the existence of the techniques.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ósseas / Fíbula Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: J Reconstr Microsurg Assunto da revista: NEUROCIRURGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ósseas / Fíbula Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: J Reconstr Microsurg Assunto da revista: NEUROCIRURGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos