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Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming.
Sanchez-Castro, E Eduardo; Pajuelo-Reyes, Cecilia; Tejedo, Rebeca; Soria-Juan, Bárbara; Tapia-Limonchi, Rafael; Andreu, Etelvina; Hitos, Ana B; Martin, Franz; Cahuana, Gladys M; Guerra-Duarte, Clara; de Assis, Thamyres C Silva; Bedoya, Francisco J; Soria, Bernat; Chávez-Olórtegui, Carlos; Tejedo, Juan R.
Afiliação
  • Sanchez-Castro EE; Faculty of Biological Sciences, Universidad Nacional Mayor de San Marcos, Lima, Peru.
  • Pajuelo-Reyes C; Institute of Tropical Diseases, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, Peru.
  • Tejedo R; Faculty of Medicine, Universidad Privada San Juan Bautista, Lima, Peru.
  • Soria-Juan B; Department of Molecular Biology and Biochemical Engineering, Universidad Pablo de Olavide, Seville, Spain.
  • Tapia-Limonchi R; Department of Surgery, Fundación Jiménez Díaz, Unidad de Terapias Avanzadas, Universidad Autónoma de Madrid, Madrid, Spain.
  • Andreu E; Institute of Tropical Diseases, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, Peru.
  • Hitos AB; ISABIAL-Hospital General y Universitario de Alicante, Alicante, Spain.
  • Martin F; Departmento de Fisica Aplicadas, University Miguel Hernández, Alicante, Spain.
  • Cahuana GM; Department of Cell Regeneration and Advanced Therapies, Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, University of Pablo de Olavide-University of Sevilla-CSIC, Seville, Spain.
  • Guerra-Duarte C; Biomedical Research Network for Diabetes and Related Metabolic Diseases-CIBERDEM, Instituto de Salud Carlos III, Madrid, Spain.
  • de Assis TCS; Department of Molecular Biology and Biochemical Engineering, Universidad Pablo de Olavide, Seville, Spain.
  • Bedoya FJ; Department of Cell Regeneration and Advanced Therapies, Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, University of Pablo de Olavide-University of Sevilla-CSIC, Seville, Spain.
  • Soria B; Biomedical Research Network for Diabetes and Related Metabolic Diseases-CIBERDEM, Instituto de Salud Carlos III, Madrid, Spain.
  • Chávez-Olórtegui C; Department of Molecular Biology and Biochemical Engineering, Universidad Pablo de Olavide, Seville, Spain.
  • Tejedo JR; Department of Cell Regeneration and Advanced Therapies, Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, University of Pablo de Olavide-University of Sevilla-CSIC, Seville, Spain.
Front Immunol ; 11: 609961, 2020.
Article em En | MEDLINE | ID: mdl-33633730
Snakebite envenoming is a global neglected disease with an incidence of up to 2.7 million new cases every year. Although antivenoms are so-far the most effective treatment to reverse the acute systemic effects induced by snakebite envenoming, they have a limited therapeutic potential, being unable to completely neutralize the local venom effects. Local damage, such as dermonecrosis and myonecrosis, can lead to permanent sequelae with physical, social, and psychological implications. The strong inflammatory process induced by snake venoms is associated with poor tissue regeneration, in particular the lack of or reduced skeletal muscle regeneration. Mesenchymal stromal cells (MSCs)-based therapies have shown both anti-inflammatory and pro-regenerative properties. We postulate that using allogeneic MSCs or their cell-free products can induce skeletal muscle regeneration in snakebite victims, improving all the three steps of the skeletal muscle regeneration process, mainly by anti-inflammatory activity, paracrine effects, neovascularization induction, and inhibition of tissue damage, instrumental for microenvironment remodeling and regeneration. Since snakebite envenoming occurs mainly in areas with poor healthcare, we enlist the principles and potential of MSCs-based therapies and discuss regulatory issues, good manufacturing practices, transportation, storage, and related-procedures that could allow the administration of these therapies, looking forward to a safe and cost-effective treatment for a so far unsolved and neglected health problem.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regeneração / Mordeduras de Serpentes / Músculo Esquelético / Desenvolvimento Muscular / Transplante de Células-Tronco Mesenquimais / Células-Tronco Mesenquimais Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: Front Immunol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Peru País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regeneração / Mordeduras de Serpentes / Músculo Esquelético / Desenvolvimento Muscular / Transplante de Células-Tronco Mesenquimais / Células-Tronco Mesenquimais Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: Front Immunol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Peru País de publicação: Suíça