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Adalimumab-induced sarcoidosis-like reaction involving oral cavity in rheumatoid arthritis: a case-based review.
Rodrigues-Fernandes, Carla Isabelly; Migliorati, Cesar Augusto; Gueiros, Luiz Alcino Monteiro; de Lima Morais, Thayná Melo; Vargas, Pablo Agustin; de Almeida, Oslei Paes; Lopes, Márcio Ajudarte; Santos-Silva, Alan Roger.
Afiliação
  • Rodrigues-Fernandes CI; Oral Diagnosis Department, Semiology and Pathology Areas, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil. carla.rodrigues212@gmail.com.
  • Migliorati CA; Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, FL, USA.
  • Gueiros LAM; Oral Medicine Unit, Department of Clinic and Preventive Dentistry, Federal University of Pernambuco, Recife, Brazil.
  • de Lima Morais TM; Oral Diagnosis Department, Semiology and Pathology Areas, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.
  • Vargas PA; Oral Diagnosis Department, Semiology and Pathology Areas, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.
  • de Almeida OP; Department of Oral Pathology, University of Pretoria, Pretoria, South Africa.
  • Lopes MA; Oral Diagnosis Department, Semiology and Pathology Areas, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.
  • Santos-Silva AR; Oral Diagnosis Department, Semiology and Pathology Areas, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.
Clin Rheumatol ; 40(9): 3833-3839, 2021 Sep.
Article em En | MEDLINE | ID: mdl-33629203
Drug-induced sarcoidosis-like reaction (DISR) is a condition almost indistinguishable from sarcoidosis, both clinically and microscopically, consisting of granulomatous tissue reaction associated with a specific therapy. Commonly affected sites are the lungs, hilar lymph nodes, and skin. This report aimed to describe a very uncommon case of DISR with an unique involvement of the oral cavity. A 63-year-old female with a history of rheumatoid arthritis, who was treated with a TNF-α antagonist (adalimumab), presented multiple ulcerative nodules on the hard palate. Laboratory tests and imaging studies failed to show any other alterations. The biopsy specimen demonstrated multiple noncaseating granulomas. Histochemical reactions were negative for acid-fast bacilli and fungi, and immunohistochemical assessment highlighted the presence of normal lymphocytes and histiocytes. With the diagnosis of DISR, adalimumab was discontinued, and complete clinical resolution of the lesions was achieved after 14 months. Although uncommon, DISR should be considered in differential diagnoses of oral granulomatous reactions, especially in cases where the patient is being treated with TNF-α antagonists.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Sarcoidose Limite: Female / Humans / Middle aged Idioma: En Revista: Clin Rheumatol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Sarcoidose Limite: Female / Humans / Middle aged Idioma: En Revista: Clin Rheumatol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha