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Protective effect of melatonin against herbicides-induced hepatotoxicity in rats.
Almeida, Lécio Leone; Pitombeira, Giovanna Silva Girão Nobre; Teixeira, Álvaro Aguiar Coelho; Teixeira, Valéria Wanderley; Silva Júnior, Valdemiro Amaro; Vieira Filho, Leucio Duarte; Evêncio Neto, Joaquim.
Afiliação
  • Almeida LL; Department of Biological Sciences, Regional University of Cariri, Rua Coronel Antônio Luís 1161, Pimenta, Crato, CE 63105-000, Brazil.
  • Pitombeira GSGN; Postgraduate Program in Biological Diversity and Natural Resources, Regional University of Cariri, Rua Coronel Antônio Luís 1161, Pimenta, Crato, CE 63105-000, Brazil.
  • Teixeira ÁAC; Department of Animal Physiology and Morfology, Federal Rural University of Pernambuco, Rua Manuel de Medeiros s/n° Dois Irmãos, Recife, PE 52171-900, Brazil.
  • Teixeira VW; Department of Animal Physiology and Morfology, Federal Rural University of Pernambuco, Rua Manuel de Medeiros s/n° Dois Irmãos, Recife, PE 52171-900, Brazil.
  • Silva Júnior VA; Department of Veterinary Medicine, Federal Rural University of Pernambuco, Rua Manuel de Medeiros s/n° Dois Irmãos, Recife, PE 52171-900, Brazil.
  • Vieira Filho LD; Department of Physiology and Pharmacology, Federal University of Pernambuco, Av. da Engenharia Cidade Universitária, Recife, PE 50670-901, Brazil.
  • Evêncio Neto J; Department of Animal Physiology and Morfology, Federal Rural University of Pernambuco, Rua Manuel de Medeiros s/n° Dois Irmãos, Recife, PE 52171-900, Brazil.
Toxicol Res (Camb) ; 10(1): 1-10, 2021 Jan.
Article em En | MEDLINE | ID: mdl-33613967
Exposure to the herbicides Paraquat and Roundup® may cause cell lesions due to an increase in oxidative stress levels in different biological systems, even in the liver. The aim of this study was to analyze the effect of melatonin on liver of rats exposed to herbicides. A total of 35 rats were randomly divided into seven equal-sized groups: control, Paraquat, Roundup®, Paraquat + Roundup®, Paraquat + melatonin, Roundup® + melatonin, and Paraquat + Roundup® + melatonin. Samples of blood and hepatic tissue were collected at the end of the seventh day of exposure and treatment with melatonin. Body weight, hematological parameters, and histopathological, biochemical analyses and determination of oxidative stress levels in liver were evaluated. Body weight was compromised (P < 0.01). Alterations of hematologic parameters were significant when compared to control (P < 0.001). Biochemically, serum levels of albumin decreased (P < 0.001), but serum levels of alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase increased (P < 0.001). Histopathology revealed necrotic hepatocytes, portal and central-lobular inflammatory infiltrate, congestion of capillaries. Serum levels of thiobarbituric acid reactive substances were found to be significantly elevated (P < 0.05; P < 0.001), and serum level of reduced glutathione was significantly lower (P < 0.05; P < 0.001). The groups treated concomitantly with melatonin revealed results similar to those of the control. However, melatonin acted as a protective agent for the liver against experimentally induced hepatic toxicity, promoting prevention of body weight, oxidative stress, and normalization of hematological and biochemical parameters.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Toxicol Res (Camb) Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Toxicol Res (Camb) Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido