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Impact of paternal exercise on physiological systems in the offspring.
Vieira de Sousa Neto, Ivo; Fontes, Wagner; Prestes, Jonato; de Cassia Marqueti, Rita.
Afiliação
  • Vieira de Sousa Neto I; Laboratory of Molecular Analysis, Graduate Program of Sciences and Technology of Health, Faculdade de Ceilândia - Universidade de Brasília, Brasília, Distrito Federal, Brazil.
  • Fontes W; Laboratory of Protein Chemistry and Biochemistry, Department of Cell Biology, Institute of Biology, Universidade de Brasília, Brasília, Distrito Federal, Brazil.
  • Prestes J; Graduate Program on Physical Education, Universidade Católica de Brasília, Brasília, Distrito Federal, Brazil.
  • de Cassia Marqueti R; Laboratory of Molecular Analysis, Graduate Program of Sciences and Technology of Health, Faculdade de Ceilândia - Universidade de Brasília, Brasília, Distrito Federal, Brazil.
Acta Physiol (Oxf) ; 231(4): e13620, 2021 04.
Article em En | MEDLINE | ID: mdl-33606364
A significant number of studies have demonstrated that paternal exercise modulates future generations via effects on the sperm epigenome. However, comprehensive information regarding the effects of exercise performed by the father on different tissues and their clinical relevance has not yet been explored in detail. This narrative review is focused on the effects of paternal exercise training on various physiological systems of offspring. A detailed mechanistic understanding of these effects could provide crucial clues for the exercise physiology field and aid the development of therapeutic approaches to mitigate disorders in future generations. Non-coding RNA and DNA methylation are major routes for transmitting epigenetic information from parents to offspring. Resistance and treadmill exercise are the most frequently used modalities of planned and structured exercise in controlled experiments. Paternal exercise orchestrated protective effects over changes in fetus development and placenta inflammatory status. Moreover paternal exercise promoted modifications in the ncRNA profiles, gene and protein expression in the hippocampus, left ventricle, skeletal muscle, tendon, liver and pancreas in the offspring, while the transgenerational effects are unknown. Paternal exercise demonstrates clinical benefits to the offspring and provides a warning on the harmful effects of a paternal unhealthy lifestyle. Exercise in fathers is presented as one of the most logical and cost-effective ways of restoring health in the offspring and, consequently, modifying the phenotype. It is important to consider that paternal programming might have unique significance in the developmental origins of offspring diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Pai Limite: Animals / Female / Humans / Male / Pregnancy Idioma: En Revista: Acta Physiol (Oxf) Assunto da revista: FISIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Pai Limite: Animals / Female / Humans / Male / Pregnancy Idioma: En Revista: Acta Physiol (Oxf) Assunto da revista: FISIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido