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Hepatitis C-related membranoproliferative glomerulonephritis in the era of direct antiviral agents.
Abdelhamid, Walid Ahmed Ragab; Shendi, Ali; Zahran, Mahmoud; Elbary, Eman Abd; Fadda, Sawsan.
Afiliação
  • Abdelhamid WAR; Zagazig University, Faculty of Medicine, Internal Medicine Department, Zagazig, Egypt.
  • Shendi A; Zagazig University, Faculty of Medicine, Internal Medicine Department, Zagazig, Egypt.
  • Zahran M; Zagazig University, Faculty of Medicine, Internal Medicine Department, Zagazig, Egypt.
  • Elbary EA; Zagazig University, Faculty of Medicine, Pathology Department, Zagazig, Egypt.
  • Fadda S; Cairo University, Faculty of Medicine, Pathology Department, Cairo, Egypt.
J Bras Nefrol ; 44(2): 291-295, 2022.
Article em En, Pt | MEDLINE | ID: mdl-33605311
Membranoproliferative glomerulonephritis (MPGN) is the most typical Hepatitis C virus (HCV)-associated glomerulopathy, and the available data about the utilization of direct-acting antivirals (DAA) in HCV-associated glomerulonephritis is inadequate. We evaluated the renal and viral response in two cases of HCV-related MPGN; the first caused by cryoglobulinemia while the second was cryoglobulin-negative. Both patients received immunosuppression besides DAA in different regimens. They achieved partial remission but remained immunosuppression-dependent for more than 6 months after DAA despite sustained virological response, which enabled safer but incomplete immunosuppression withdrawal. Both patients were tested for occult HCV in peripheral blood mononuclear cells and found to be negative. Hence, the treatment of HCV-related MPGN ought to be according to the clinical condition and the effects of drug therapy. It is important to consider that renal response can lag behind the virological response.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glomerulonefrite Membranoproliferativa / Hepatite C / Hepatite C Crônica / Glomerulonefrite Tipo de estudo: Etiology_studies Limite: Humans Idioma: En / Pt Revista: J Bras Nefrol Assunto da revista: NEFROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Egito País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glomerulonefrite Membranoproliferativa / Hepatite C / Hepatite C Crônica / Glomerulonefrite Tipo de estudo: Etiology_studies Limite: Humans Idioma: En / Pt Revista: J Bras Nefrol Assunto da revista: NEFROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Egito País de publicação: Brasil