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Decreased classical monocytes and CD163 expression in TB patients: an indicator of drug resistance.
Shahzad, Faheem; Bashir, Noman; Ali, Atia; Jabeen, Shagufta; Kashif, Mohammad; Javaid, Khursheed; Tahir, Romeeza; Abbas, Afia; Jahan, Shah; Afzal, Nadeem.
Afiliação
  • Shahzad F; Department of Immunology, University of Health Sciences, Khayaban-e-Jamia Punjab, Lahore, 54600, Pakistan. Faheem599@gmail.com.
  • Bashir N; Department of Livestock Management, Agriculture University Faisalabad, Faisalabad, Pakistan.
  • Ali A; Department of Immunology, University of Health Sciences, Khayaban-e-Jamia Punjab, Lahore, 54600, Pakistan.
  • Jabeen S; Department of Immunology, University of Health Sciences, Khayaban-e-Jamia Punjab, Lahore, 54600, Pakistan.
  • Kashif M; Department of Immunology, University of Health Sciences, Khayaban-e-Jamia Punjab, Lahore, 54600, Pakistan.
  • Javaid K; Department of Immunology, University of Health Sciences, Khayaban-e-Jamia Punjab, Lahore, 54600, Pakistan.
  • Tahir R; Department of Immunology, University of Health Sciences, Khayaban-e-Jamia Punjab, Lahore, 54600, Pakistan.
  • Abbas A; Department of Immunology, University of Health Sciences, Khayaban-e-Jamia Punjab, Lahore, 54600, Pakistan.
  • Jahan S; Department of Immunology, University of Health Sciences, Khayaban-e-Jamia Punjab, Lahore, 54600, Pakistan.
  • Afzal N; Department of Immunology, University of Health Sciences, Khayaban-e-Jamia Punjab, Lahore, 54600, Pakistan.
Braz J Microbiol ; 52(2): 607-617, 2021 Jun.
Article em En | MEDLINE | ID: mdl-33586094
Tuberculosis (TB) is a disease instigated by Mycobacterium tuberculosis. Peripheral blood monocytes represent highly efficient effector cells of innate immunity against TB. Little is known about monocyte subsets and their potential involvement in the development of M. tuberculosis drug resistance in patients with TB. This study was conducted to investigate alterations in monocyte subsets, CD163 expression on monocytes, and its serum level in patients without and with rifampicin resistance TB (RR-TB) and healthy controls. A total of 164 patients with TB (84 without RR-TB and 80 patients with RR-TB) and 85 healthy controls were enrolled in this study. The percentages of various monocyte subsets and surface expression of CD163 on monocytes were quantitatively determined using flow cytometry. The serum level of CD163 was determined by commercially available ELISA kits. Decreased frequency of classical monocytes was detected in patients with RR-TB. Non-classical monocytes were decreased in patients without RR-TB; however, intermediate monocytes were raised in patients with RR-TB. The serum level of CD163 was decreased in patients of RR-TB that showsed a positive correlation with the frequency of CD14++CD16-CD163+ and CD14++CD16+CD163+ monocytes. It is concluded that decreased classical monocytes and sCD163 in patients with RR-TB could be an indicator of drug resistance.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Monócitos / Antígenos de Diferenciação Mielomonocítica / Antígenos CD / Receptores de Superfície Celular / Farmacorresistência Bacteriana / Mycobacterium tuberculosis / Antituberculosos Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Braz J Microbiol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Paquistão País de publicação: Brasil
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Monócitos / Antígenos de Diferenciação Mielomonocítica / Antígenos CD / Receptores de Superfície Celular / Farmacorresistência Bacteriana / Mycobacterium tuberculosis / Antituberculosos Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Braz J Microbiol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Paquistão País de publicação: Brasil