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Carotid body chemoreceptors: physiology, pathology, and implications for health and disease.
Iturriaga, Rodrigo; Alcayaga, Julio; Chapleau, Mark W; Somers, Virend K.
Afiliação
  • Iturriaga R; Laboratorio de Neurobiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile, and Centro de Excelencia en Biomedicina de Magallanes, Universidad de Magallanes, Punta Arenas, Chile.
  • Alcayaga J; Laboratorio de Fisiología Celular, Facultad de Ciencias, Universidad de Chile, Santiago, Chile.
  • Chapleau MW; Department of Internal Medicine, University of Iowa and Department of Veterans Affairs Medical Center, Iowa City, Iowa.
  • Somers VK; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
Physiol Rev ; 101(3): 1177-1235, 2021 07 01.
Article em En | MEDLINE | ID: mdl-33570461
The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2 and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to maintain homeostasis. This review examines the fundamental biology underlying CB chemoreceptor function, its contribution to integrated physiological responses, and its role in maintaining health and potentiating disease. Emphasis is placed on 1) transduction mechanisms in chemoreceptor (type I) cells, highlighting the role played by the hypoxic inhibition of O2-dependent K+ channels and mitochondrial oxidative metabolism, and their modification by intracellular molecules and other ion channels; 2) synaptic mechanisms linking type I cells and petrosal nerve terminals, focusing on the role played by the main proposed transmitters and modulatory gases, and the participation of glial cells in regulation of the chemosensory process; 3) integrated reflex responses to CB activation, emphasizing that the responses differ dramatically depending on the nature of the physiological, pathological, or environmental challenges, and the interactions of the chemoreceptor reflex with other reflexes in optimizing oxygen delivery to the tissues; and 4) the contribution of enhanced CB chemosensory discharge to autonomic and cardiorespiratory pathophysiology in obstructive sleep apnea, congestive heart failure, resistant hypertension, and metabolic diseases and how modulation of enhanced CB reactivity in disease conditions may attenuate pathophysiology.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Nervoso Autônomo / Corpo Carotídeo / Células Quimiorreceptoras / Hipóxia Limite: Animals / Humans Idioma: En Revista: Physiol Rev Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Chile País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Nervoso Autônomo / Corpo Carotídeo / Células Quimiorreceptoras / Hipóxia Limite: Animals / Humans Idioma: En Revista: Physiol Rev Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Chile País de publicação: Estados Unidos