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Persistent High-Risk HPV Infection and Molecular Changes Related to the Development of Cervical Cancer.
Moreno-Acosta, Pablo; Romero-Rojas, Alfredo; Vial, Nicolas; Huertas, Antonio; Acosta, Jinneth; Mayorga, Diana; Carrillo, Schyrly; Molano, Monica; Gamboa, Oscar; Cotes, Martha; Casadiego, Camila; Vallard, Alexis; Magne, Nicolas.
Afiliação
  • Moreno-Acosta P; Research Group in Radiobiology Clinical, Molecular and Cellular, National Cancer Institute, Bogota, Colombia.
  • Romero-Rojas A; Research Group in Cancer Biology, National Cancer Institute, Bogota, Colombia.
  • Vial N; Group of Pathology Oncology, National Cancer Institute, Bogota, Colombia.
  • Huertas A; Department of Radiation Oncology, Institut de cancérologie de la Loire-Lucien Neuwirth, 108 bis, Avenue Albert Raimond, BP 60008, 42271 Saint-Priest en Jarez, France.
  • Acosta J; Biobank, Group of Pathology Oncology, National Cancer Institute, Bogota, Colombia.
  • Mayorga D; Pathology Group, National University of Colombia, Bogota, Colombia.
  • Carrillo S; Research Group in Radiobiology Clinical, Molecular and Cellular, National Cancer Institute, Bogota, Colombia.
  • Molano M; Research Group in Cancer Biology, National Cancer Institute, Bogota, Colombia.
  • Gamboa O; Microbiology and Infection Diseases, The Royal Women's Hospital, Melbourne, Australia.
  • Cotes M; Unit of Analysis, National Cancer Institute, Bogota, Colombia.
  • Casadiego C; Group Area Radiotherapy Oncology, National Cancer Institute, Bogota, Colombia.
  • Vallard A; Group Area Radiotherapy Oncology, National Cancer Institute, Bogota, Colombia.
  • Magne N; Department of Radiation Oncology, Institut de cancérologie de la Loire-Lucien Neuwirth, 108 bis, Avenue Albert Raimond, BP 60008, 42271 Saint-Priest en Jarez, France.
Case Rep Obstet Gynecol ; 2020: 6806857, 2020.
Article em En | MEDLINE | ID: mdl-33552605
This article is a preliminary investigational study that is aimed at giving hints about the interesting biomarkers involved in the transition process from low-grade cervix lesion to invasive cervical cancer. Our study focuses on the risk factors and tumour molecular changes in one patient. First in 1986, she was diagnosed a preinvasive cervix lesion. Then, 16 years later, she was diagnosed an invasive cervical cancer. The 2002 diagnosis was a squamous cell carcinoma of the cervix, stage IIIB (FIGO), whereas in 1986, she had been diagnosed a high-grade squamous intraepithelial cervical lesion. Retrospectively, the analysis of samples of preneoplastic lesions and invasive cervical cancer confirmed the histopathological diagnoses and detected the presence of HPV type and HPV-16 variants, as well as the overexpression of proteins such as hTERT, IGF1Rα, IGF1Rß, CAIX, and GLUT1. Finally, the Arg72Pro polymorphism was detected in TP53. The role of high-risk HPV and HPV-16 variants and of hTERT, IGF1Rα, IGF1Rß, CAIX, and GLUT1 variations seemed confirmed in the development and progression of cervical cancer. As a result, analyzing the molecular changes in one and same tumour that progresses from a low-grade cervix lesion to invasive cervical cancer could provide valuable information in order to improve detection, diagnosis, and treatment in the future.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies Idioma: En Revista: Case Rep Obstet Gynecol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies Idioma: En Revista: Case Rep Obstet Gynecol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Estados Unidos