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[Formula: see text]Socioeconomic aspects are crucial to better intellectual outcome in early-treated adolescents with congenital hypothyroidism.
de Andrade, Jéssica Evelyn; Dias, Vera Maria Alves; Jardim de Paula, Jonas; Silva, Ivani Novato.
Afiliação
  • de Andrade JE; Pediatrics Department, Division of Pediatric Endocrinology, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Dias VMA; Pediatrics Department, Division of Pediatric Endocrinology, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Jardim de Paula J; Laboratory of Neurosciences, Universidade Federal de Minas Gerais, Department of Psychology, Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Silva IN; Pediatrics Department, Division of Pediatric Endocrinology, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Child Neuropsychol ; 27(5): 587-600, 2021 07.
Article em En | MEDLINE | ID: mdl-33533679
Congenital hypothyroidism (CH) is an important cause of preventable intellectual disability. Implementation of CH neonatal screening programs leading to early treatment has improved cognitive outcome. However, more subtle cognitive impairments are still reported, and there is lack of clarity regarding factors that impact long-term cognitive outcome. Research to better understand these factors can lead to further improvements in the cognitive prognosis for these patients. The current study aimed to evaluate the cognitive performance of adolescents who were early-treated for primary permanent CH and possible associated variables. Neurocognitive evaluation was carried out in 66 adolescents, 11 to 16 years old: 34 with CH and 29 paired controls. Intellectual quotient (IQ), verbal fluency, processing speed, executive functions, and memory were investigated. CH patients and control subjects were comparable regarding sex, age, schooling, family's socioeconomic status and caregiver's educational level. Both groups presented not only similar IQ scores but also equivalent performances regarding Perceptual Reasoning, Working Memory and Processing Speed index scores. Patients presenting different CH etiologies (dysgenesis and dyshormonogenesis) showed similar cognitive performance. Socioeconomic aspects along with the initial levothyroxine dose were the main variables to positively influence the cognitive performance, the family's socioeconomic status having the strongest association with patients' cognitive skills.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipotireoidismo Congênito Tipo de estudo: Prognostic_studies Aspecto: Determinantes_sociais_saude Limite: Adolescent / Child / Humans / Newborn Idioma: En Revista: Child Neuropsychol Assunto da revista: NEUROLOGIA / PSICOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipotireoidismo Congênito Tipo de estudo: Prognostic_studies Aspecto: Determinantes_sociais_saude Limite: Adolescent / Child / Humans / Newborn Idioma: En Revista: Child Neuropsychol Assunto da revista: NEUROLOGIA / PSICOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido