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Novel Sterile Insect Technology Program Results in Suppression of a Field Mosquito Population and Subsequently to Reduced Incidence of Dengue.
de Castro Poncio, Lisiane; Dos Anjos, Filipe Apolinário; de Oliveira, Deborah A; Rebechi, Débora; de Oliveira, Rodrigo Neves; Chitolina, Rodrigo Faitta; Fermino, Marise Lopes; Bernardes, Luciano G; Guimarães, Danton; Lemos, Pedro A; Silva, Marcelo N E; Silvestre, Rodrigo G M; Bernardes, Emerson Soares; Paldi, Nitzan.
Afiliação
  • de Castro Poncio L; Forrest Brasil Tecnologia Ltda, Araucaria, Brazil.
  • Dos Anjos FA; Forrest Brasil Tecnologia Ltda, Araucaria, Brazil.
  • de Oliveira DA; Forrest Brasil Tecnologia Ltda, Araucaria, Brazil.
  • Rebechi D; Forrest Brasil Tecnologia Ltda, Araucaria, Brazil.
  • de Oliveira RN; Forrest Brasil Tecnologia Ltda, Araucaria, Brazil.
  • Chitolina RF; Forrest Brasil Tecnologia Ltda, Araucaria, Brazil.
  • Fermino ML; Forrest Brasil Tecnologia Ltda, Araucaria, Brazil.
  • Bernardes LG; Faculty of Health Sciences of Barretos Dr Paulo Prata, Barretos, Brazil.
  • Guimarães D; Paraná Institute of Technology, Curitiba, Brazil.
  • Lemos PA; Sanitary Surveillance of Jacarezinho Municipal Health Department, Jacarezinho, Brazil.
  • Silva MNE; Epidemiologic Surveillance of Jacarezinho Municipal Health Department, Jacarezinho, Brazil.
  • Silvestre RGM; Health Department of Jacarezinho, Jacarezinho, Brazil.
  • Bernardes ES; UniSociesc, Curitiba, Brazil.
  • Paldi N; University of São Paulo, São Paulo, Brazil.
J Infect Dis ; 224(6): 1005-1014, 2021 09 17.
Article em En | MEDLINE | ID: mdl-33507265
BACKGROUND: There is a steady rise in the global incidence of Aedes-borne arbovirus disease. It has become urgent to develop alternative solutions for mosquito vector control. We developed a new method of sterilization of male mosquitoes with the goal to suppress a local Aedes aegypti population and to prevent the spread of dengue. METHODS: Sterile male mosquitoes were produced from a locally acquired Ae. aegypti colony by using a treatment that includes double-stranded RNA and thiotepa. A field study was conducted with sterile mosquito releases being performed on a weekly basis in predefined areas. There were 2 intervention periods (INT1 and INT2), with treatment and control areas reversed between INT1 and INT2. RESULTS: During INT1, releases in the treated area resulted in up to 91.4% reduction of live progeny of field Ae. aegypti mosquitoes recorded over time, while the control neighborhoods (no releases of sterile male mosquitoes) remained highly infested. The successful implementations of the program during INT1 and INT2 were associated with 15.9-fold and 13.7-fold lower incidences of dengue in the treated area compared to the control areas, respectively. CONCLUSIONS: Our data show the success of this new sterile insect technology-based program in preventing the spread of dengue.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Controle de Mosquitos / Aedes / Dengue / Mosquitos Vetores Tipo de estudo: Incidence_studies / Prognostic_studies / Risk_factors_studies Limite: Animals País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Infect Dis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Controle de Mosquitos / Aedes / Dengue / Mosquitos Vetores Tipo de estudo: Incidence_studies / Prognostic_studies / Risk_factors_studies Limite: Animals País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Infect Dis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos