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Antimicrobial photodynamic therapy can be an effective adjuvant for surgical wound healing in cattle.
Valandro, Patrícia; Massuda, Mayara B; Rusch, Elidiane; Birgel, Daniela B; Pereira, Philipe P L; Sellera, Fábio P; Ribeiro, Martha S; Pogliani, Fabio C; Birgel Junior, Eduardo H.
Afiliação
  • Valandro P; Department of Veterinary Medicine, School of Animal Science and Food Engineering University of São Paulo, Pirassununga, Brazil.
  • Massuda MB; Department of Veterinary Medicine, School of Animal Science and Food Engineering University of São Paulo, Pirassununga, Brazil.
  • Rusch E; Department of Veterinary Medicine, School of Animal Science and Food Engineering University of São Paulo, Pirassununga, Brazil.
  • Birgel DB; Department of Veterinary Medicine, School of Animal Science and Food Engineering University of São Paulo, Pirassununga, Brazil.
  • Pereira PPL; Department of Internal Medicine, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
  • Sellera FP; Department of Internal Medicine, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil; School of Veterinary Medicine, Metropolitan University of Santos, Santos, Brazil.
  • Ribeiro MS; Center for Lasers and Applications, Nuclear, and Energy Research Institute, National Commission for Nuclear Energy, São Paulo, SP, Brazil.
  • Pogliani FC; Department of Internal Medicine, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
  • Birgel Junior EH; Department of Veterinary Medicine, School of Animal Science and Food Engineering University of São Paulo, Pirassununga, Brazil. Electronic address: ehbirgel@usp.br.
Photodiagnosis Photodyn Ther ; 33: 102168, 2021 Mar.
Article em En | MEDLINE | ID: mdl-33497814
BACKGROUND: Rumenostomy is a useful procedure commonly performed in cattle for medical treatment of domestic ruminants with forestomach diseases. Methylene blue (MB)-mediated antimicrobial photodynamic therapy (APDT) has been broadly investigated to treat infected wounds. AIM: The aim of the study was to evaluate the effectiveness of MB-mediated APDT (MB-APDT) combined with chlorhexidine and zinc oxide ointment on wound healing process after rumenostomy. METHODS: Fourteen Nelore bulls were subjected to rumenostomy procedure. Animals were randomly divided into MB-APDT (MB associated with a red diode laser performed immediately after surgery and repeated on days 3, 5, 7 and 10) and control groups. Daily care included topical cleaning with chlorhexidine 2% followed by topical zinc oxide ointment. Animals were followed-up until the 28th day. RESULTS: Wounds presented a better post-surgical profile in MB-APDT group when it was compared with the control group. In MB-APDT group, it was also possible to observe less pain on palpation of wounds borders, less edema and inflammatory exudate. Additionally, animals from MB-APDT group were faster discharged from the cattle care facility. CONCLUSION: Our results support the use of MB-APDT for the post-surgical management of rumenostomy. This pilot study ratifies the use of APDT in cattle and also suggests that it could be performed for other surgical procedures as a complementary approach or an alternative for topical administration of antibiotics.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Ferida Cirúrgica / Anti-Infecciosos Limite: Animals Idioma: En Revista: Photodiagnosis Photodyn Ther Assunto da revista: DIAGNOSTICO POR IMAGEM / TERAPEUTICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Ferida Cirúrgica / Anti-Infecciosos Limite: Animals Idioma: En Revista: Photodiagnosis Photodyn Ther Assunto da revista: DIAGNOSTICO POR IMAGEM / TERAPEUTICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda