Your browser doesn't support javascript.
loading
Photobiomodulation Therapy (Light-Emitting Diode 630 nm) Favored the Oxidative Stress and the Preservation of Articular Cartilage in an Induced Knee Osteoarthritis Model.
Martins, Lorena Pacheco de Oliveira; Santos, Flávia Franciele Dos; Costa, Thais Eugênio Duarte; Lacerda, Ana Cristina Rodrigues; Santos, Jousielle Márcia Dos; Costa, Karine Beatriz; Santos, Ana Paula; Gaiad, Thaís Peixoto; Pinfildi, Carlos Eduardo; Rocha-Vieira, Etel; Mendonça, Vanessa Amaral; Xavier Oliveira, Murilo.
Afiliação
  • Martins LPO; Department of Physical Therapy, School of Biological and Health Sciences, Universidade Federal dos Vales do Jequitinhonha e do Mucuri (UFVJM), Diamantina, Minas Gerais, Brazil.
  • Santos FFD; Department of Physical Therapy, School of Biological and Health Sciences, Universidade Federal dos Vales do Jequitinhonha e do Mucuri (UFVJM), Diamantina, Minas Gerais, Brazil.
  • Costa TED; Department of Physical Therapy, School of Biological and Health Sciences, Universidade Federal dos Vales do Jequitinhonha e do Mucuri (UFVJM), Diamantina, Minas Gerais, Brazil.
  • Lacerda ACR; Department of Physical Therapy, School of Biological and Health Sciences, Universidade Federal dos Vales do Jequitinhonha e do Mucuri (UFVJM), Diamantina, Minas Gerais, Brazil.
  • Santos JMD; Department of Physical Therapy, School of Biological and Health Sciences, Universidade Federal dos Vales do Jequitinhonha e do Mucuri (UFVJM), Diamantina, Minas Gerais, Brazil.
  • Costa KB; Department of Physical Therapy, School of Biological and Health Sciences, Universidade Federal dos Vales do Jequitinhonha e do Mucuri (UFVJM), Diamantina, Minas Gerais, Brazil.
  • Santos AP; Department of Physical Therapy, School of Biological and Health Sciences, Universidade Federal dos Vales do Jequitinhonha e do Mucuri (UFVJM), Diamantina, Minas Gerais, Brazil.
  • Gaiad TP; Department of Physical Therapy, School of Biological and Health Sciences, Universidade Federal dos Vales do Jequitinhonha e do Mucuri (UFVJM), Diamantina, Minas Gerais, Brazil.
  • Pinfildi CE; Department of Human Movement Sciences, Federal University of São Paulo (UNIFESP)-Campus Baixada Santista, Santos, São Paulo, Brazil.
  • Rocha-Vieira E; Faculty of Medicine, Universidade Federal dos Vales do Jequitinhonha e do Mucuri (UFVJM), Diamantina, Minas Gerais, Brazil.
  • Mendonça VA; Department of Physical Therapy, School of Biological and Health Sciences, Universidade Federal dos Vales do Jequitinhonha e do Mucuri (UFVJM), Diamantina, Minas Gerais, Brazil.
  • Xavier Oliveira M; Department of Physical Therapy, School of Biological and Health Sciences, Universidade Federal dos Vales do Jequitinhonha e do Mucuri (UFVJM), Diamantina, Minas Gerais, Brazil.
Photobiomodul Photomed Laser Surg ; 39(4): 272-279, 2021 Apr.
Article em En | MEDLINE | ID: mdl-33497593
Objective: To evaluate the effects of photobiomodulation (PBM) therapy on oxidative stress and histological aspects of knee osteoarthritis (OA) induced by sodium monoiodoacetate in Wistar rats. Background: OA is a chronic degenerative disease. In addition to the inflammatory role, other factors, such as redox balance, appear to contribute to changes in the articular cartilage, the main articular structure affected. PBM therapy using light-emitting diode (LED) has been proposed to treat the disease by favoring anti-inflammatory effects and modulating markers of oxidative stress, acting on the degenerative process of cartilage. Methods: Twenty-seven male rats were separated into three groups: control (CG), OA (OAG), and LED treatment (LEDG). In the LED group, PBM (LED 630 nm, 300 mW, 9 J/cm2, 0.3 W/cm2, 30 sec) was applied, starting 24 h after induction, three times per week, for 8 weeks. Cartilage thickness, number of chondrocytes, enzymatic antioxidant defenses [superoxide dismutase (SOD) and catalase (CAT)], oxidative damage [thiobarbituric acid reactive substances (TBARS)], and nonenzymatic defense (ferric reducing antioxidant power) were analyzed. Results: The LEDG had higher average cartilage thickness compared with the OAG and had similar thickness to the CG. Also, the number of chondrocytes was similar to the CG. In the oxidative stress analysis, the LEDG presented antioxidant enzymatic activity (SOD and CAT) higher than the CG, and presented concentration of TBARS lower than the CG and OAG groups. Conclusions: PBM therapy was effective in recovering oxidative stress and preserving the articular cartilage aspects in a knee OA animal model.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cartilagem Articular / Osteoartrite do Joelho / Terapia com Luz de Baixa Intensidade Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Photobiomodul Photomed Laser Surg Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cartilagem Articular / Osteoartrite do Joelho / Terapia com Luz de Baixa Intensidade Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Photobiomodul Photomed Laser Surg Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos