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Pharmacokinetics of amoxicillin in obese and nonobese subjects.
Soares, Ana Luiza P P D P; Montanha, Maiara C; Alcantara, Conrado D S; Silva, Sandra R B; Kuroda, Cristina M; Yamada, Sérgio S; Nicacio, Antônio E; Maldaner, Liane; Visentainer, Jesui V; Simões, Caroline F; Locatelli, João Carlos; Lopes, Wendell A; Mazucheli, Josmar; Diniz, Andrea; Paixão, Paulo J P A; Kimura, Elza.
Afiliação
  • Soares ALPPDP; Postgraduate Program in Biosciences and Physiopathology (PBF), Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
  • Montanha MC; Clinical Research Centre and Bioequivalence Studies, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
  • Alcantara CDS; Research Associate Department of Molecular & Clinical Pharmacology, University of Liverpool, Liverpool, UK.
  • Silva SRB; Clinical Research Centre and Bioequivalence Studies, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
  • Kuroda CM; Clinical Research Centre and Bioequivalence Studies, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
  • Yamada SS; Clinical Research Centre and Bioequivalence Studies, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
  • Nicacio AE; Clinical Research Centre and Bioequivalence Studies, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
  • Maldaner L; Postgraduate Program in Chemistry, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
  • Visentainer JV; Departament of Chemistry, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
  • Simões CF; Departament of Chemistry, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
  • Locatelli JC; Postgraduate Program in Physical Education, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
  • Lopes WA; Postgraduate Program in Physical Education, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
  • Mazucheli J; Department of Physical Education, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
  • Diniz A; Department of Statistics, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
  • Paixão PJPA; Department of Pharmacy, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
  • Kimura E; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.
Br J Clin Pharmacol ; 87(8): 3227-3233, 2021 08.
Article em En | MEDLINE | ID: mdl-33474776
AIMS: To compare the pharmacokinetics of amoxicillin (AMX) in obese and nonobese subjects, given as single dose 875-mg tablets. METHODS: A prospective, single-centre, open-label, clinical study was carried out involving 10 nonobese and 20 obese subjects given a dose of an AMX 875-mg tablet. Serial blood samples were collected between 0 and 8 hours after administration of AMX and plasma levels were quantified by liquid chromatography-tandem mass spectrometry. The pharmacokinetic parameters (PK) were calculated by noncompartmental analysis and means of the 2 groups were compared using Student t-test. Analysis of correlation between covariates and PK was performed using Pearson's correlation coefficient. RESULTS: Ten nonobese subjects (mean age 30.6 ± 7.12 y; body mass index 21.56 ± 1.95 kg/m2 ) and 20 obese subjects (mean age 34.47 ± 7.03 y; body mass index 33.17 ± 2.38 kg/m2 ) participated in the study. Both maximum concentration (Cmax ; 12.12 ± 4.06 vs. 9.66 ± 2.93 mg/L) and area under the curve (AUC)0-inf (34.18 ± 12.94 mg.h/L vs. 26.88 ± 9.24 mg.h/L) were slightly higher in nonobese than in obese subjects, respectively, but differences were not significant. The volume of distribution (V/F) parameter was statistically significantly higher in obese compared to nonobese patients (44.20 ± 17.85 L vs. 27.57 ± 12.96 L). Statistically significant correlations were observed for several weight metrics vs. AUC, Cmax , V/F and clearance, and for creatinine clearance vs. AUC, Cmax and clearance. CONCLUSION: In obese subjects, the main altered PK was V/F as a consequence of greater body weight. This may result in antibiotic treatment failure if standard therapeutic regimens are administered.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Amoxicilina / Obesidade Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Humans Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Amoxicilina / Obesidade Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Humans Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido