An update on brown adipose tissue biology: a discussion of recent findings.

Gaspar, Rafael C; Pauli, José R; Shulman, Gerald I; Muñoz, Vitor R

Gaspar, Rafael C; Pauli, José R; Shulman, Gerald I; Muñoz, Vitor R.

Afiliação

Gaspar RC; Department of Health Sciences, Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, São Paulo, Brazil.
Pauli JR; Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Shulman GI; Department of Health Sciences, Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, São Paulo, Brazil.
Muñoz VR; OCRC-Obesity and Comorbidities Research Center, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.

Am J Physiol Endocrinol Metab ; 320(3): E488-E495, 2021 03 01.

Article em En | MEDLINE | ID: mdl-33459179

RESUMO

Brown adipose tissue (BAT) has been encouraged as a potential treatment for obesity and comorbidities due to its thermogenic activity capacity and contribution to energy expenditure. Some interventions such as cold and ß-adrenergic drugs are able to activate BAT thermogenesis as well as promote differentiation of white adipocytes into brown-like cells (browning), enhancing the thermogenic activity of these cells. In this mini-review, we discuss new mechanisms related to BAT and energy expenditure. In this regard, we will also discuss recent studies that have revealed the existence of important secretory molecules from BAT "batokines" that act in autocrine, paracrine, and endocrine mechanisms, which in turn may explain some of the beneficial roles of BAT on whole body glucose and fat metabolism. Finally, we will discuss new insights related to BAT thermogenesis with an additional focus on the distinct features of BAT metabolism between rodents and humans.

Assuntos

Tecido Adiposo Marrom/fisiologia; Adipócitos Brancos/metabolismo; Animais; Metabolismo Energético/fisiologia; Glucose/metabolismo; Humanos; Termogênese/fisiologia

Palavras-chave

batokines; brown adipose tissue; thermogenesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tecido Adiposo Marrom Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: Am J Physiol Endocrinol Metab Assunto da revista: ENDOCRINOLOGIA / FISIOLOGIA / METABOLISMO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

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