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Gut microbiota modulation induced by Zika virus infection in immunocompetent mice.
Corrêa, Rafael; de Oliveira Santos, Igor; Braz-de-Melo, Heloísa Antoniella; de Sant'Ana, Lívia Pimentel; das Neves Almeida, Raquel; Pasquarelli-do-Nascimento, Gabriel; Prado, Paulo Sousa; Kobinger, Gary P; Maurice, Corinne F; Magalhães, Kelly Grace.
Afiliação
  • Corrêa R; Laboratory of Immunology and Inflammation, Department of Cell Biology, University of Brasilia, Brasília, DF, Brazil.
  • de Oliveira Santos I; Laboratory of Immunology and Inflammation, Department of Cell Biology, University of Brasilia, Brasília, DF, Brazil.
  • Braz-de-Melo HA; Laboratory of Immunology and Inflammation, Department of Cell Biology, University of Brasilia, Brasília, DF, Brazil.
  • de Sant'Ana LP; Laboratory of Immunology and Inflammation, Department of Cell Biology, University of Brasilia, Brasília, DF, Brazil.
  • das Neves Almeida R; Laboratory of Immunology and Inflammation, Department of Cell Biology, University of Brasilia, Brasília, DF, Brazil.
  • Pasquarelli-do-Nascimento G; Laboratory of Immunology and Inflammation, Department of Cell Biology, University of Brasilia, Brasília, DF, Brazil.
  • Prado PS; Central Laboratory of Federal District (LACEN), Brasília, Brazil.
  • Kobinger GP; Département de Microbiologie-Infectiologie et d'Immunologie, Université Laval, Quebec, Canada.
  • Maurice CF; Centre de Recherche en Infectiologie du CHU de Québec-Université Laval, Quebec, Canada.
  • Magalhães KG; Department of Microbiology and Immunology, McGill University, Montreal, Canada.
Sci Rep ; 11(1): 1421, 2021 01 14.
Article em En | MEDLINE | ID: mdl-33446825
Gut microbiota composition can modulate neuroendocrine function, inflammation, and cellular and immunological responses against different pathogens, including viruses. Zika virus (ZIKV) can infect adult immunocompetent individuals and trigger brain damage and antiviral responses. However, it is not known whether ZIKV infection could impact the gut microbiome from adult immunocompetent mice. Here, we investigated modifications induced by ZIKV infection in the gut microbiome of immunocompetent C57BL/6J mice. Adult C57BL/6J mice were infected with ZIKV and the gut microbiota composition was analyzed by next-generation sequencing of the V4 hypervariable region present in the bacterial 16S rDNA gene. Our data showed that ZIKV infection triggered a significant decrease in the bacteria belonging to Actinobacteria and Firmicutes phyla, and increased Deferribacteres and Spirochaetes phyla components compared to uninfected mice. Interestingly, ZIKV infection triggered a significant increase in the abundance of bacteria from the Spirochaetaceae family in the gut microbiota. Lastly, we demonstrated that modulation of microbiota induced by ZIKV infection may lead to intestinal epithelium damage and intense leukocyte recruitment to the intestinal mucosa. Taken together, our data demonstrate that ZIKV infection can impact the gut microbiota composition and colon tissue homeostasis in adult immunocompetent mice.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Spirochaetaceae / Firmicutes / Microbioma Gastrointestinal / Zika virus / Infecção por Zika virus / Mucosa Intestinal Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Spirochaetaceae / Firmicutes / Microbioma Gastrointestinal / Zika virus / Infecção por Zika virus / Mucosa Intestinal Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido