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Impact of Tdap vaccine during pregnancy on the incidence of pertussis in children under one year in Brazil - A time series analysis.
Santana, Clarice Paiva; Luhm, Karin Regina; Shimakura, Silvia Emiko.
Afiliação
  • Santana CP; Universidade Federal do Paraná (UFPR), Postgraduate Program in Public Health - Curitiba, Rua Padre Camargo, 280 - Alto da Glória, Curitiba, PR 80060-240, Brazil. Electronic address: claricepaiva@hotmail.com.
  • Luhm KR; Universidade Federal do Paraná (UFPR), Postgraduate Program in Public Health - Curitiba, Rua Padre Camargo, 280 - Alto da Glória, Curitiba, PR 80060-240, Brazil.
  • Shimakura SE; Universidade Federal do Paraná (UFPR), Statistics Department, Centro Politécnico, sn - Jd Américas, Curitiba, PR 81531-990, Brazil.
Vaccine ; 39(6): 976-983, 2021 02 05.
Article em En | MEDLINE | ID: mdl-33446384
Pertussis is a globally distributed infectious disease that is a significant cause of morbidity and mortality, especially in infants who are too young to be immunized. This disease is common in childhood, and when it occurs during the first few months of life, it leads to hospitalization and, sometimes, death. Brazil has adopted the strategy of maternal immunization against pertussis in late 2014. This study aims to analyze public data on the disease to determine whether there was an impact on the disease burden following the introduction of the vaccine Tdap in pregnant women and its magnitude. We performed a time-series analysis of the incidence of pertussis between October 2010 and January 2019. We stratified the population of interest into three groups: infants aged less than two months old, infants aged two to six months, and infants aged six months to one year, according to Brazil's vaccination schedule. We found a protective effect of maternal vaccination in all age groups, more prominent on the first group. Before the intervention, infants under two months had a higher risk of getting pertussis in comparison with infants two to six months old (HR 1.15, CI 95%: 1.11-1.19). After the intervention, age under two months is a protective factor compared with two to six months (HR 0.90, CI 95%: 0.82-0.98). The pertussis incidence reduced in all age groups and all Brazil's Regions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Coqueluche / Vacinas contra Difteria, Tétano e Coqueluche Acelular Tipo de estudo: Incidence_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Female / Humans / Infant / Pregnancy País/Região como assunto: America do sul / Brasil Idioma: En Revista: Vaccine Ano de publicação: 2021 Tipo de documento: Article País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Coqueluche / Vacinas contra Difteria, Tétano e Coqueluche Acelular Tipo de estudo: Incidence_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Female / Humans / Infant / Pregnancy País/Região como assunto: America do sul / Brasil Idioma: En Revista: Vaccine Ano de publicação: 2021 Tipo de documento: Article País de publicação: Holanda