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The clinical and pathogenic spectrum of surgically-induced scleral necrosis: A review.
Ruiz-Lozano, Raul E; Garza-Garza, Lucas A; Davila-Cavazos, Osvaldo; Foster, C Stephen; Rodriguez-Garcia, Alejandro.
Afiliação
  • Ruiz-Lozano RE; Tecnologico de Monterrey, School of Medicine and Health Sciences, Institute of Ophthalmology and Visual Sciences, Monterrey, Mexico.
  • Garza-Garza LA; Tecnologico de Monterrey, School of Medicine and Health Sciences, Institute of Ophthalmology and Visual Sciences, Monterrey, Mexico.
  • Davila-Cavazos O; Tecnologico de Monterrey, School of Medicine and Health Sciences, Institute of Ophthalmology and Visual Sciences, Monterrey, Mexico.
  • Foster CS; Massachusetts Eye Research and Surgery Institute, Waltham, MA, USA; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
  • Rodriguez-Garcia A; Tecnologico de Monterrey, School of Medicine and Health Sciences, Institute of Ophthalmology and Visual Sciences, Monterrey, Mexico. Electronic address: immuneye@gmail.com.
Surv Ophthalmol ; 66(4): 594-611, 2021.
Article em En | MEDLINE | ID: mdl-33422510
The onset of scleral necrosis after ocular surgery may have catastrophic ocular and systemic consequences. The two most frequent surgeries causing surgically-induced scleral necrosis (SISN) are pterygium excision and cataract extraction. Several pathogenic mechanisms are involved in surgically induced scleral necrosis. All of them are poorly understood. Ocular trauma increasing lytic action of collagenases with subsequent collagen degradation, vascular disruption leading to local ischemia, and immune complex deposition activating the complement system represents some of the events that lead to scleral necrosis. The complex cascade of events involving different pathogenic mechanisms and the patient's abnormal immune response frequently leads to delayed wound healing that predisposes the development of scleral necrosis. The management of SISN ranges from short-term systemic anti-inflammatory drugs to aggressive immunosuppressive therapy and surgical repair. Therefore, before performing any ocular surgery involving the sclera, a thorough ophthalmic and systemic evaluation must be done to identify high-risk patients that may develop SISN.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pterígio / Esclerite Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Revista: Surv Ophthalmol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pterígio / Esclerite Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Revista: Surv Ophthalmol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos