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Sirolimus-Loaded Intravitreal Implant for Effective Treatment of Experimental Uveitis.
Paiva, Mayara Rodrigues Brandão De; Vasconcelos-Santos, Daniel Vítor; Vieira, Lorena Carla; Fialho, Sílvia Ligório; Silva-Cunha, Armando.
Afiliação
  • Paiva MRB; Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, 31270-901, Minas Gerais, Brazil. mrbprodrigues@gmail.com.
  • Vasconcelos-Santos DV; Pharmaceutical Research and Development, Ezequiel Dias Foundation, Belo Horizonte, 30510-010, Minas Gerais, Brazil. mrbprodrigues@gmail.com.
  • Vieira LC; Department of Ophthalmology e Otorhinolaryngology, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
  • Fialho SL; Pharmaceutical Research and Development, Ezequiel Dias Foundation, Belo Horizonte, 30510-010, Minas Gerais, Brazil.
  • Silva-Cunha A; Pharmaceutical Research and Development, Ezequiel Dias Foundation, Belo Horizonte, 30510-010, Minas Gerais, Brazil.
AAPS PharmSciTech ; 22(1): 35, 2021 Jan 06.
Article em En | MEDLINE | ID: mdl-33404988
Non-infectious uveitis, an ocular inflammatory condition that affects the iris, ciliary body, choroid, and adjacent tissues (retina, optic nerve, and vitreous), is an important cause of blindness worldwide. Sirolimus (SRL), a potent immunomodulatory drug, has shown promising results in the treatment of inflammatory ocular diseases. Despite this therapeutic potential, its clinical use is a major challenge due to low bioavailability and poor solubility. Poly(lactic-co-glycolic acid) (PLGA) is a biodegradable polymer commonly used for ophthalmic drug delivery due to its suitable characteristics such as biocompatibility, good mechanical properties, and improvement of the pharmacokinetic profile of the drug. In the present study, we investigated the effects of SRL-PLGA implant on experimental autoimmune uveitis in rabbits. Clinical and histopathological examinations were performed, followed by assessment of protein levels and determination of myeloperoxidase (MPO) and N-acetylglucosaminidase (NAG) activity in the aqueous humor/vitreous. As a result, treated eyes had decreased average inflammatory scores, protein significant decreases in treated eyes, assessed after 35 days. Histopathological examination showed less severe intraocular inflammation and decreased tissue damage in treated eyes. According to these results, the SRL-PLGA implant evaluated in this study was apparently safe, reducing inflammation in treated eyes, with an extended effect possibly associated with prolonged release of SRL in the posterior segment of the eye. Therefore, intravitreal SRL-PLGA implant could be a promising alternative for treatment of non-infectious uveitis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Uveíte / Corpo Vítreo / Sirolimo / Implantes de Medicamento / Imunossupressores Limite: Animals Idioma: En Revista: AAPS PharmSciTech Assunto da revista: FARMACOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Uveíte / Corpo Vítreo / Sirolimo / Implantes de Medicamento / Imunossupressores Limite: Animals Idioma: En Revista: AAPS PharmSciTech Assunto da revista: FARMACOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos