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Nuclear abnormalities in umbilical cord blood lymphocytes of newborns from the Ahome and Guasave municipalities in Sinaloa, Mexico.
Martínez-Valenzuela, Carmen; Huichapan, José; Ortega, Luis Daniel; Irineo, Ana Bertha; Zenteno, Edgar; Ruiz-Ramos, Rubén.
Afiliação
  • Martínez-Valenzuela C; Institute for Research in Environment and Health, Autonomous University of Occident, Bulevar Macario Gaxiola y Carretera Internacional, Los Mochis, Sinaloa, Mexico.
  • Huichapan J; Institute for Research in Environment and Health, Autonomous University of Occident, Bulevar Macario Gaxiola y Carretera Internacional, Los Mochis, Sinaloa, Mexico.
  • Ortega LD; Department of Biological Sciences, Popular Autonomous University of the State of Puebla, 13 Poniente 1927 Colonia Barrio de Santiago, Puebla, Mexico.
  • Irineo AB; Faculty of Medicine, Autonomous University of Occident, Bulevar Macario Gaxiola y Carretera Internacional, Los Mochis, Sinaloa, Mexico.
  • Zenteno E; Faculty of Medicine, National Autonomous University of Mexico, Ciudad Universitaria, Coyoacán, México City, Mexico.
  • Ruiz-Ramos R; Faculty of Medicine, Veracruz University, Agustín de Iturbide S/N, Zona Centro, Veracruz, Mexico.
J Obstet Gynaecol Res ; 47(3): 968-977, 2021 Mar.
Article em En | MEDLINE | ID: mdl-33372370
AIM: We measured the frequency of nuclear abnormalities of 210 blood samples from the umbilical cord, since human fetuses are exposed to environmental mixtures of pesticides that induce DNA damage. METHODS: The determinations were made through the micronucleus assay test in lymphocytes from the umbilical cord blood of newborns whose mothers live in Ahome (n = 105) and Guasave (n = 105), Sinaloa, Mexico. RESULTS: The average frequency of anomalies in 1000 cells were, respectively: micronucleus 0.4 vs. 2.9, pyknotic cells 18.3 vs. 109.2, chromatin condensation 7.7 vs. 150.1, karyolitic cells 1.8 vs. 24.4, and binucleated cells 4.9 vs. 74.6. The calculated Pearson correlation factors of nuclear abnormality frequencies between both municipalities were low and negative, suggesting that they did not correlate between the Ahome and Guasave newborns and indicating a higher number of mothers exposed in Guasave. CONCLUSION: Our data suggest that monitoring nuclear abnormalities in umbilical cord blood samples could be a useful tool to identify transplacental mutagens perfusion that is being discharged into the local environment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos / Sangue Fetal Tipo de estudo: Prognostic_studies Limite: Humans / Newborn País/Região como assunto: Mexico Idioma: En Revista: J Obstet Gynaecol Res Assunto da revista: GINECOLOGIA / OBSTETRICIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Austrália
Texto completo
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XML
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos / Sangue Fetal Tipo de estudo: Prognostic_studies Limite: Humans / Newborn País/Região como assunto: Mexico Idioma: En Revista: J Obstet Gynaecol Res Assunto da revista: GINECOLOGIA / OBSTETRICIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Austrália