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Histological and Nanomechanical Properties of a New Nanometric Hydroxiapatite Implant Surface. An In Vivo Study in Diabetic Rats.
Oliveira, Paula G F P; Coelho, Paulo G; Bergamo, Edmara T P; Witek, Lukasz; Borges, Cristine A; Bezerra, Fábio B; Novaes, Arthur B; Souza, Sergio L S.
Afiliação
  • Oliveira PGFP; Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Av do Café, s/n., Ribeirao Preto, SP 14040-904, Brazil.
  • Coelho PG; Hansjorg Wyss Department of Plastic Surgery, New York University School of Medicine, New York, NY 10010, USA.
  • Bergamo ETP; Hansjorg Wyss Department of Plastic Surgery, New York University School of Medicine, New York, NY 10010, USA.
  • Witek L; Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York, NY 10010, USA.
  • Borges CA; Departments of Mechanical and Aerospace Engineering, New York University Tandon School of Engineering, 433 1st avenue,8th floor, Brooklyn, New York, NY 10010, USA.
  • Bezerra FB; Department of Prosthodontic and Periodontology, Bauru School of Dentistry, University of Sao Paulo, Av. Octavio Pinheiro Brisolla9-75, Bauru, SP 17012-901, Brazil.
  • Novaes AB; Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York, NY 10010, USA.
  • Souza SLS; Departments of Biomedical Engineering, New York University Tandon School of Engineering, 433 1st avenue, 8th floor, Brooklyn, New York, NY 10010, USA.
Materials (Basel) ; 13(24)2020 Dec 13.
Article em En | MEDLINE | ID: mdl-33322243
Implant therapy is a predictable treatment to replace missing teeth. However, the osseointegration process may be negatively influenced by systemic conditions, such as diabetes mellitus (DM). Microtopography and implant surface developments are strategies associated to better bone repair. This study aimed to evaluate, in healthy and diabetic rats, histomorphometric (bone to implant contact = %BIC; and bone area fraction occupancy = %BAFO) and nanomechanical (elastic modulus = EM; and hardness = H) bone parameters, in response to a nanometric hydroxyapatite implant surface. Mini implants (machined = MAC; double acid etched = DAE, and with addition of nano-hydroxyapatite = NANO) were installed in tibias of healthy and diabetic rats. The animals were euthanized at 7 and 30 days. NANO surface presented higher %BIC and %BAFO when compared to MAC and DAE (data evaluated as a function of implant surface). NANO surface presented higher %BIC and %BAFO, with statistically significant differences (data as a function of time and implant surface). NANO surface depicted higher EM and H values, when compared to machined and DAE surfaces (data as a function of time and implant surface). Nano-hydroxyapatite coated implants presented promising biomechanical results and could be an important tool to compensate impaired bone healing reported in diabetics.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Materials (Basel) Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Materials (Basel) Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça