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Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals.
Bonin, Carla Rezende Barbosa; Fernandes, Guilherme Côrtes; de Menezes Martins, Reinaldo; Camacho, Luiz Antonio Bastos; Teixeira-Carvalho, Andréa; da Mota, Licia Maria Henrique; de Lima, Sheila Maria Barbosa; Campi-Azevedo, Ana Carolina; Martins-Filho, Olindo Assis; Dos Santos, Rodrigo Weber; Lobosco, Marcelo.
Afiliação
  • Bonin CRB; Institute of Education, Science and Technology of Southeast of Minas Gerais - Cataguases Advanced Campus, Chácara Granjaria, s/n - Granjaria, 36773-563, Cataguases, Brazil. rezendebonin@gmail.com.
  • Fernandes GC; Medical School, Presidente Antônio Carlos University, Juiz de Fora, Brazil.
  • de Menezes Martins R; Bio-Manguinhos Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.
  • Camacho LAB; Sergio Arouca National School of Public Health (ENSP), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.
  • Teixeira-Carvalho A; René Rachou Research Center, Oswaldo Cruz Foundation (FIOCRUZ)/Minas, Belo Horizonte, Brazil.
  • da Mota LMH; Rheumatology Department, University of Brasilia (UnB), Brasilia, Brazil.
  • de Lima SMB; Bio-Manguinhos Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.
  • Campi-Azevedo AC; René Rachou Research Center, Oswaldo Cruz Foundation (FIOCRUZ)/Minas, Belo Horizonte, Brazil.
  • Martins-Filho OA; René Rachou Research Center, Oswaldo Cruz Foundation (FIOCRUZ)/Minas, Belo Horizonte, Brazil.
  • Dos Santos RW; Graduate Program in Computational Modeling, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Brazil.
  • Lobosco M; Graduate Program in Computational Modeling, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Brazil.
BMC Bioinformatics ; 21(Suppl 17): 551, 2020 Dec 14.
Article em En | MEDLINE | ID: mdl-33308151
BACKGROUND: An effective yellow fever (YF) vaccine has been available since 1937. Nevertheless, questions regarding its use remain poorly understood, such as the ideal dose to confer immunity against the disease, the need for a booster dose, the optimal immunisation schedule for immunocompetent, immunosuppressed, and pediatric populations, among other issues. This work aims to demonstrate that computational tools can be used to simulate different scenarios regarding YF vaccination and the immune response of individuals to this vaccine, thus assisting the response of some of these open questions. RESULTS: This work presents the computational results obtained by a mathematical model of the human immune response to vaccination against YF. Five scenarios were simulated: primovaccination in adults and children, booster dose in adult individuals, vaccination of individuals with autoimmune diseases under immunomodulatory therapy, and the immune response to different vaccine doses. Where data were available, the model was able to quantitatively replicate the levels of antibodies obtained experimentally. In addition, for those scenarios where data were not available, it was possible to qualitatively reproduce the immune response behaviours described in the literature. CONCLUSIONS: Our simulations show that the minimum dose to confer immunity against YF is half of the reference dose. The results also suggest that immunological immaturity in children limits the induction and persistence of long-lived plasma cells are related to the antibody decay observed experimentally. Finally, the decay observed in the antibody level after ten years suggests that a booster dose is necessary to keep immunity against YF.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Febre Amarela / Vacina contra Febre Amarela / Modelos Teóricos Limite: Adult / Child / Humans Idioma: En Revista: BMC Bioinformatics Assunto da revista: INFORMATICA MEDICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Febre Amarela / Vacina contra Febre Amarela / Modelos Teóricos Limite: Adult / Child / Humans Idioma: En Revista: BMC Bioinformatics Assunto da revista: INFORMATICA MEDICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido