Your browser doesn't support javascript.
loading
"Association of APOE gene polymorphisms with primary open angle glaucoma in Brazilian patients".
Occhiutto, Marcelo Luís; de Melo, Mônica Barbosa; Cabral de Vasconcellos, José Paulo; Rodrigues, Thiago Adalton Rosa; Bajano, Flávia Fialho; Costa, Fernando Ferreira; Costa, Vital Paulino.
Afiliação
  • Occhiutto ML; Department of Ophthalmology, Faculty of Medical Sciences, University of Campinas - UNICAMP , Campinas, Brazil.
  • de Melo MB; Laboratory of Human Genetics, Center for Molecular Biology and Genetic Engineering - CBMEG , Campinas, Brazil.
  • Cabral de Vasconcellos JP; Department of Ophthalmology, Faculty of Medical Sciences, University of Campinas - UNICAMP , Campinas, Brazil.
  • Rodrigues TAR; Laboratory of Human Genetics, Center for Molecular Biology and Genetic Engineering - CBMEG , Campinas, Brazil.
  • Bajano FF; Laboratory of Human Genetics, Center for Molecular Biology and Genetic Engineering - CBMEG , Campinas, Brazil.
  • Costa FF; Hematology and Hemotherapy Center, University of Campinas - UNICAMP , Campinas, Brazil.
  • Costa VP; Department of Ophthalmology, Faculty of Medical Sciences, University of Campinas - UNICAMP , Campinas, Brazil.
Ophthalmic Genet ; 42(1): 53-61, 2021 02.
Article em En | MEDLINE | ID: mdl-33287609
Background: Primary open-angle glaucoma (POAG) is a multifactorial disease that affects 65.5 million people worldwide. In addition to the genetic variants already established as indicators of greater risk for POAG, the apolipoprotein (APOE) gene has been studied in some populations, with controversial results. The aim of this study is to investigate the frequency of the genetic variants of APOE in the Brazilian population, and to evaluate the association between these polymorphisms and the risk of POAG. Methods: APOE variants (rs429358; rs7412) were genotyped in 402 POAG patients and 401 controls. We evaluated the association between APOE genetic variants and the risk for POAG, as well as the correlation between the requirement of glaucoma surgery and the APOE polymorphisms. Results: Among the three APOE gene isoforms, we found a low frequency of APOE alleles ε2 (7.34%) and ε4 (11.76%), but a high frequency of ε3 (80.88%) in our population. When compared to ε3ε3 reference genotype, ε2 allele-carriers (OR = 1.516; p-value = 0.04) and ε2ε3 genotype (OR = 1.655; p-value = 0.02) were associated with a greater risk for POAG. An additive genetic model confirmed the influence of the ε2 allele in the risk of POAG in this sample of the Brazilian population (OR = 1.502; p-value = 0.04). There was no significant association between the analyzed genotypes and the requirement or number of glaucoma surgeries (p > .05). Conclusion: Brazilian individuals carrying the APOEε2 allele may be at an increased risk for the development of POAG.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apolipoproteínas E / Glaucoma de Ângulo Aberto / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Ophthalmic Genet Assunto da revista: GENETICA MEDICA / OFTALMOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apolipoproteínas E / Glaucoma de Ângulo Aberto / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Ophthalmic Genet Assunto da revista: GENETICA MEDICA / OFTALMOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido