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Optical clearing agent increases effectiveness of photodynamic therapy in a mouse model of cutaneous melanoma: an analysis by Raman microspectroscopy.
Martinelli, Letícia Palombo; Iermak, Ievgeniia; Moriyama, Lilian Tan; Requena, Michelle Barreto; Pires, Layla; Kurachi, Cristina.
Afiliação
  • Martinelli LP; Federal University of São Carlos, Post-Graduation Program inBiotechnology, Rodovia Washington Luís km 235, SP-310, São Carlos 13565-905, Brazil.
  • Iermak I; University of São Paulo, São Carlos Institute of Physics, Avenue Trabalhador São-Carlense, 400, São Carlos, São Paulo 13566-590, Brazil.
  • Moriyama LT; leticia.martinelli@usp.br.
  • Requena MB; University of São Paulo, São Carlos Institute of Physics, Avenue Trabalhador São-Carlense, 400, São Carlos, São Paulo 13566-590, Brazil.
  • Pires L; University of São Paulo, São Carlos Institute of Physics, Avenue Trabalhador São-Carlense, 400, São Carlos, São Paulo 13566-590, Brazil.
  • Kurachi C; University of São Paulo, São Carlos Institute of Physics, Avenue Trabalhador São-Carlense, 400, São Carlos, São Paulo 13566-590, Brazil.
Biomed Opt Express ; 11(11): 6516-6527, 2020 Nov 01.
Article em En | MEDLINE | ID: mdl-33282505
Melanoma is the most aggressive type of skin cancer and a relevant health problem due to its poor treatment response with high morbidity and mortality rates. This study, aimed to investigate the tissue changes of an improved photodynamic therapy (PDT) response when combined with optical clearing agent (OCA) in the treatment of cutaneous melanoma in mice. Photodithazine (PDZ) was administered intraperitoneally and a solution of OCA was topically applied before PDT irradiation. Due to a resultant refractive index matching, OCA-treated tumors are more optically homogenous, improving the PDT response. Raman analysis revealed, when combined with OCA, the PDT response was more homogenous down to 725 µm-depth in thickness.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biomed Opt Express Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biomed Opt Express Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos