Your browser doesn't support javascript.
loading
The Prion-like Properties of Amyloid-beta Peptide and Tau: Is there Any Risk of Transmitting Alzheimer's Disease During Neurosurgical Interventions?
Padilla-Zambrano, Huber S; García-Ballestas, Ezequiel; Quiñones-Ossa, Gabriel A; Sibaja-Perez, Andrés E; Agrawal, Amit; Moscote-Salazar, Luis R; Menéndez-González, Manuel.
Afiliação
  • Padilla-Zambrano HS; Center for Biomedical Research (CIB), Faculty of Medicine, University of Cartagena, Cartagena, Colombia.
  • García-Ballestas E; Center for Biomedical Research (CIB), Faculty of Medicine, University of Cartagena, Cartagena, Colombia.
  • Quiñones-Ossa GA; Faculty of Medicine, El Bosque University, Bogota, Colombia.
  • Sibaja-Perez AE; Center for Biomedical Research (CIB), Faculty of Medicine, University of Cartagena, Cartagena, Colombia.
  • Agrawal A; Department of Neurosurgery, Narayana Medical College, Nellore, Andhra Pradesh, India.
  • Moscote-Salazar LR; Neurosurgeon-Critical Care, Center for Biomedical Research (CIB), Faculty of Medicine, University of Cartagena, Cartagena de Indias, Bolivar, Colombia.
  • Menéndez-González M; Neurology Service, Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain.
Curr Alzheimer Res ; 17(9): 781-789, 2020.
Article em En | MEDLINE | ID: mdl-33280597
Recent studies have recognized similarities between the peptides involved in the neuropathology of Alzheimer's disease and prions. The Tau protein and the Amyloid ß peptide represent the theoretical pillars of Alzheimer's disease development. It is probable that there is a shared mechanism for the transmission of these substances and the prion diseases development; this presumption is based on the presentation of several cases of individuals without risk factors who developed dementia decades after a neurosurgical procedure. This article aims to present the role of Aß and Tau, which underlie the pathophysiologic mechanisms involved in the AD and their similarities with the prion diseases infective mechanisms by means of the presentation of the available evidence at molecular (in-vitro), animal, and human levels that support the controversy on whether these diseases might be transmitted in neurosurgical interventions, which may constitute a wide public health issue.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Proteínas tau / Procedimentos Neurocirúrgicos / Doença de Alzheimer / Proteínas Priônicas Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Curr Alzheimer Res Assunto da revista: NEUROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Emirados Árabes Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Proteínas tau / Procedimentos Neurocirúrgicos / Doença de Alzheimer / Proteínas Priônicas Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Curr Alzheimer Res Assunto da revista: NEUROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Emirados Árabes Unidos