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Clinical, histopathologic, and immunohistochemical features of 13 cases of canine gallbladder neuroendocrine carcinoma.
O'Brien, Kevin M; Bankoff, Braelyn J; Rosenstein, Peri K; Clendaniel, Daphne C; Sánchez, Melissa D; Durham, Amy C.
Afiliação
  • O'Brien KM; Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA.
  • Bankoff BJ; Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA.
  • Rosenstein PK; Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA.
  • Clendaniel DC; Mid-Atlantic Veterinary Specialists, Malvern, PA.
  • Sánchez MD; Antech Diagnostics, Framingham, MA.
  • Durham AC; Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA.
J Vet Diagn Invest ; 33(2): 294-299, 2021 Mar.
Article em En | MEDLINE | ID: mdl-33267749
In this retrospective descriptive study, we characterized the clinical, histologic, and immunohistochemical features of 13 cases of canine gallbladder neuroendocrine carcinoma (GB-NEC). Immunohistochemical stains for neuroendocrine (neuron-specific enolase [NSE], chromogranin A, synaptophysin) and gastrin markers were evaluated, and clinicopathologic and follow-up data were obtained for all cases. The average age at diagnosis was 8.9 y, and breeds included 6 Boston Terriers, 2 Bichon Frise, 1 Poodle, 1 English Bulldog, 1 French Bulldog, and 2 mixed-breed dogs. Boston Terriers were overrepresented in this cohort, and therefore a breed predilection is possible. Most dogs were presented with emesis and elevated liver enzyme activities: 13 of 13 had elevated alanine aminotransferase and alkaline phosphatase activities; 8 of 13 had elevated aspartate aminotransferase activity; 7 of 13 had elevated gamma-glutamyl transferase activity. Abdominal ultrasound and/or exploratory surgery revealed a gallbladder mass. All neoplasms had similar histologic features and positive immunoreactivity for NSE, chromogranin A, synaptophysin, and gastrin. Vascular invasion was noted in 8 of 13 neoplasms, and metastasis was present in 6 of 13 cases (4 hepatic and 2 pulmonary metastases). The median survival time was 3.7 y in patients who died; 5 of 8 deaths were directly attributed to the GB-NEC, 3 of which had metastatic spread. GB-NECs have the potential to metastasize; however, surgical excision may be curative in a subset of dogs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Neuroendócrino / Doenças do Cão / Neoplasias da Vesícula Biliar Tipo de estudo: Diagnostic_studies / Observational_studies Limite: Animals País/Região como assunto: America do norte Idioma: En Revista: J Vet Diagn Invest Assunto da revista: MEDICINA VETERINARIA Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Neuroendócrino / Doenças do Cão / Neoplasias da Vesícula Biliar Tipo de estudo: Diagnostic_studies / Observational_studies Limite: Animals País/Região como assunto: America do norte Idioma: En Revista: J Vet Diagn Invest Assunto da revista: MEDICINA VETERINARIA Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos