Assessment of SNP-SNP interactions by using square contingency table analysis.

KaradaG, Özge; Altun, GÖkÇen; AktaS, Serpil

KaradaG, Özge; Altun, GÖkÇen; AktaS, Serpil.

Afiliação

KaradaG Ö; Hacettepe University, Department of Statistics, 06800, Beytepe, Ankara, Turkey.
Altun G; Bartin University, Department of Computer Technology and Information Systems, 74100, Bartin, Turkey.
AktaS S; Hacettepe University, Department of Statistics, 06800, Beytepe, Ankara, Turkey.

An Acad Bras Cienc ; 92(3): e20190465, 2020.

Article em En | MEDLINE | ID: mdl-33263659

RESUMO

The evolution of SNP-SNP interactions has become an interesting field in genetic epidemiology. Most of the studies, aimed to analyze the relationship between genetic factors and disease of interest, are focused on single SNP associations. However, for quantitative traits, influenced by the interplay of environmental and more than one genetic factors, interaction between the multi factors should be taken into consideration. In this study, symmetry models for square contingency tables are applied to the cross-classified SNP-SNP interactions data. Results from a genome-wide association analysis of blood pressure are used as a prior evidence for the interacted SNPs.

Assuntos

Estudo de Associação Genômica Ampla; Polimorfismo de Nucleotídeo Único; Fenótipo; Polimorfismo de Nucleotídeo Único/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo de Nucleotídeo Único / Estudo de Associação Genômica Ampla Tipo de estudo: Prognostic_studies Idioma: En Revista: An Acad Bras Cienc Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil

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