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Time-Dependent Effect of Platelet-Rich Plasma in Reducing Donor-Site Pain After Anterior Cruciate Ligament Reconstruction.
de Andrade, André Luís Lugnani; Sardeli, Amanda Veiga; Garcia, Thiago Alves; Livani, Bruno; Belangero, William Dias.
Afiliação
  • de Andrade ALL; Faculty of Medical Sciences, University of Campinas-UNICAMP, Campinas-SP, Brazil.
  • Sardeli AV; Laboratory of Exercise Physiology-FISEX, University of Campinas-UNICAMP, Campinas-SP, Brazil.
  • Garcia TA; Orthopaedic Biomaterials Laboratory, School of Medical Sciences, University of Campinas-UNICAMP, Campinas-SP, Brazil.
  • Livani B; Faculty of Medical Sciences, University of Campinas-UNICAMP, Campinas-SP, Brazil.
  • Belangero WD; Faculty of Medical Sciences, University of Campinas-UNICAMP, Campinas-SP, Brazil.
Am J Sports Med ; 49(10): 2854-2858, 2021 08.
Article em En | MEDLINE | ID: mdl-33253008
BACKGROUND: Anterior cruciate ligament reconstruction (ACLR) has a high incidence among sports players, and one important side effect of the surgery is graft donor site morbidity. Although some evidence suggests that application of platelet-rich plasma (PRP) during ACLR reduces pain and improves knee function, it is not a universal finding. PURPOSE: To perform a meta-analysis of previous studies testing the effects of PRP on donor site morbidity after ACLR. STUDY DESIGN: Systematic review and meta-analysis. METHODS: We reviewed PubMed (Medline), Web of Science, Embase, Scopus, and Cochrane databases to find studies testing the effects of PRP on the donor site of ACLR autograft. After identifying 4 studies, we conducted 2 meta-analyses, 1 for the effects of PRP on pain, assessed by visual analog scale (VAS), and the other for the functional knee scores. We also tested the ability of time after ACLR to predict the PRP-related reduction of pain. RESULTS: In the 4 studies identified, 157 patients were analyzed. Although the VAS score was lower with PRP at 6 months (raw mean difference [RMD], -0.97 [95% CI, -1.59 to -0.36]; P = .001) and 12 months (RMD, -0.61 [95% CI,-1.02 to -0.21]; P = .003), the effects of PRP disappeared at 24 months (RMD, -0.08 [95% CI,-0.38 to 0.22]; P = .586). A univariate regression analysis reinforced the ability of time after ACLR to predict the PRP-related reduction of VAS pain score (r2 = 0.98). However, knee function after ACLR was not improved by the use of PRP (standardized mean difference, 0.71 [95% CI,-0.17 to 1.60]; P = .114). CONCLUSION: PRP applied to a bone-patellar tendon-bone donor site could reduce knee pain within a year, and this reduction had a correlation with time, meaning that the effect of PRP decreased with time after surgery. However, pain reduction did not reach clinical relevance and did not lead to better functional knee scores.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ligamento Patelar / Plasma Rico em Plaquetas / Reconstrução do Ligamento Cruzado Anterior / Lesões do Ligamento Cruzado Anterior Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Am J Sports Med Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ligamento Patelar / Plasma Rico em Plaquetas / Reconstrução do Ligamento Cruzado Anterior / Lesões do Ligamento Cruzado Anterior Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Am J Sports Med Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos