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A simple score derived from bone marrow immunophenotyping is important for prognostic evaluation in myelodysplastic syndromes.
Vido-Marques, J R; Reis-Alves, S C; Saad, S T O; Metze, K; Lorand-Metze, I.
Afiliação
  • Vido-Marques JR; Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, Brazil.
  • Reis-Alves SC; Hematology and Hemotherapy Center, University of Campinas, Carlos Chagas Street, 480, Campinas, São Paulo, 13083-878, Brazil.
  • Saad STO; Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, Brazil.
  • Metze K; Hematology and Hemotherapy Center, University of Campinas, Carlos Chagas Street, 480, Campinas, São Paulo, 13083-878, Brazil.
  • Lorand-Metze I; Department of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, Brazil.
Sci Rep ; 10(1): 20281, 2020 11 20.
Article em En | MEDLINE | ID: mdl-33219285
Immunophenotyping of bone marrow (BM) precursors has been used as an ancillary diagnostic tool in myelodysplastic syndromes (MDS), but there is no general agreement about which variables are the most relevant for prognosis. We developed a parsimonious prognostic model based on BM cell populations well-defined by phenotype. We analyzed 95 consecutive patients with primary MDS diagnosed at our Institution between 2005 and 2012 where BM immunophenotyping had been performed at diagnosis. Median follow-up: 42 months (4-199). Median age: 67 years (33-79). According to IPSS-R, 71 cases were low or intermediate risk. Flow variables significant in the univariate Cox analysis: "%monocytes/TNCs", "% CD16+ monocytes/TNCs", "total alterations in monocytes", "% myeloid CD34+ cells", "number of abnormal expressions in myeloblasts" and "% of B-cell progenitors". In the multivariate model remained independent: "% myeloid CD34+ cells", B-cell progenitors" and "% CD16+ monocytes/TNCs". These variables were categorized by the extreme quartile risk ratio strategy in order to build the score: % myeloid CD34+ cells" (≥ 2.0% = 1 point), B-cell progenitors" (< 0.05% 1 point) and "CD16+ monocytes/TNCs" (≥ 1.0% 1 point). This score could separate patients with a different survival. There was a weak correlation between the score and IPSS-R. Both had independent prognostic values and so, the flow score adds value for the prognostic evaluation in MDS.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medula Óssea / Síndromes Mielodisplásicas / Células da Medula Óssea / Modelos Estatísticos Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medula Óssea / Síndromes Mielodisplásicas / Células da Medula Óssea / Modelos Estatísticos Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido