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Saliva NMR-Based Metabolomics in the War Against COVID-19.
Costa Dos Santos Junior, Gilson; Pereira, Claudia Maria; Kelly da Silva Fidalgo, Tatiana; Valente, Ana Paula.
Afiliação
  • Costa Dos Santos Junior G; Laboratory of NMR Metabolomics, IBRAG, Department of Genetics, State University of Rio de Janeiro, Boulevard 28 de Setembro 77 fds, Vila Isabel, RJ, 20551-030 Rio de Janeiro, Brazil.
  • Pereira CM; Postgraduate Program in Translational Biomedicine, Grande Rio University, Rua Professor José de Souza Herdy, 1160, Jardim Vinte e Cinco de Agosto, 25071-202 Duque de Caxias, Brazil.
  • Kelly da Silva Fidalgo T; Dental School, Department of Preventive and Community Dentistry, State University of Rio de Janeiro, Boulevard 28 de Setembro, 157, Vila Isabel, 20551-030 Rio de Janeiro, Brazil.
  • Valente AP; BioNMR, CENABIO I, Department of Structural Biology, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373, CCS/bloco K-anexo, 21941-599 Rio de Janeiro, Brazil.
Anal Chem ; 92(24): 15688-15692, 2020 12 15.
Article em En | MEDLINE | ID: mdl-33215503
COVID-19 is an emergent, worldwide public health concern. Joint efforts have been made by scientific communities of various fields to better understand the mechanisms of action of SARS-CoV-2. The need to understand the pathophysiological fingerprint and pathways of this disease make metabolomics-related approaches an indispensable tool for properly answering concerns relating to disease course. Determination of the metabolomic profile may help to explain the heterogeneous spectra of COVID-19 clinical phenotypes and be useful in monitoring disease progression as well as therapeutic treatments. In this sense, saliva has proven to be a strategic biofluid, owing not only to its appeal as a noninvasive sampling method but also due to the capacity of the virus to invade epithelial cells of the oral mucosa and salivary gland ducts via ACE2 receptors. Accordingly, important changes in metabolism have been described relating to COVID-19, indicating that metabolomics may open new avenues for understanding the pathophysiology of this disease, especially via longitudinal study designs. Thus, we discuss the importance of comprehending the SARS-CoV-2 salivary metabolomic fingerprint and also highlight the situation of Brazil on the frontlines of the war against COVID-19.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glândulas Salivares / Ressonância Magnética Nuclear Biomolecular / Metabolômica / SARS-CoV-2 / COVID-19 Tipo de estudo: Observational_studies Limite: Humans Idioma: En Revista: Anal Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glândulas Salivares / Ressonância Magnética Nuclear Biomolecular / Metabolômica / SARS-CoV-2 / COVID-19 Tipo de estudo: Observational_studies Limite: Humans Idioma: En Revista: Anal Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos