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Bronchoalveolar Lavage in Systemic Sclerosis Patients: A Systematic Review.
da Silva, Sérgio Oliveira; da Paz, Adriane Souza; Farias, Isla Miranda Vidal Cavalcante; Moreira, Damille Sandes; Ribeiro, Marianna Alegro Fontes; Alves, Tatiana Senna Galvão Nonato; Lemos, Antônio Carlos Moreira; Santiago, Mittermayer Barreto.
Afiliação
  • da Silva SO; Complexo Hospitalar Universitário Professor Edgard Santos, Rua Doutor Augusto Viana, s/n, Canela, CEP 40110-060, Salvador, Bahia, Brazil.
  • da Paz AS; Complexo Hospitalar Universitário Professor Edgard Santos, Rua Doutor Augusto Viana, s/n, Canela, CEP 40110-060, Salvador, Bahia, Brazil.
  • Farias IMVC; Complexo Hospitalar Universitário Professor Edgard Santos, Rua Doutor Augusto Viana, s/n, Canela, CEP 40110-060, Salvador, Bahia, Brazil.
  • Moreira DS; Complexo Hospitalar Universitário Professor Edgard Santos, Rua Doutor Augusto Viana, s/n, Canela, CEP 40110-060, Salvador, Bahia, Brazil.
  • Ribeiro MAF; Complexo Hospitalar Universitário Professor Edgard Santos, Rua Doutor Augusto Viana, s/n, Canela, CEP 40110-060, Salvador, Bahia, Brazil.
  • Alves TSGN; Complexo Hospitalar Universitário Professor Edgard Santos, Rua Doutor Augusto Viana, s/n, Canela, CEP 40110-060, Salvador, Bahia, Brazil.
  • Lemos ACM; Complexo Hospitalar Universitário Professor Edgard Santos, Rua Doutor Augusto Viana, s/n, Canela, CEP 40110-060, Salvador, Bahia, Brazil.
  • Santiago MB; Complexo Hospitalar Universitário Professor Edgard Santos, Rua Doutor Augusto Viana, s/n, Canela, CEP 40110-060, Salvador, Bahia, Brazil.
Curr Rheumatol Rev ; 17(2): 176-183, 2021.
Article em En | MEDLINE | ID: mdl-33185168
INTRODUCTION: We performed a systematic review of the literature to determine the value of bronchoalveolar lavage (BAL) in evaluating the pulmonary involvement of systemic sclerosis (SSc). METHODS: Articles published between 1980 and 2019 were retrieved from the databases: PubMed and Scielo. The search was restricted to clinical trials published in English, utilizing the keywords "scleroderma, systemic sclerosis, interstitial lung disease, and bronchoalveolar lavage". RESULTS: Twenty-two papers were analyzed. A positive correlation was observed between increased BAL cellularity (alveolitis) and worsening clinical symptoms, pulmonary function, and radiological pattern in 2, 11, and 15 studies, respectively. The majority of BAL studies that evaluated interleukin levels, including TNF-α, IL-6, IL-7, and IL-8, observed higher levels in patients with impaired pulmonary function and increased lung involvement. CONCLUSIONS: Alveolitis and the increase of some cytokines/chemokines in BAL were related to more severe pulmonary disease in SSc in the majority of the studies and seemed to be markers of worse prognosis, but it is unknown whether BAL adds clinical value to the use of the other non-invasive diagnostic procedures.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Escleroderma Sistêmico / Doenças Pulmonares Intersticiais / Lavagem Broncoalveolar Tipo de estudo: Etiology_studies / Prognostic_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Curr Rheumatol Rev Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Emirados Árabes Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Escleroderma Sistêmico / Doenças Pulmonares Intersticiais / Lavagem Broncoalveolar Tipo de estudo: Etiology_studies / Prognostic_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Curr Rheumatol Rev Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Emirados Árabes Unidos