Your browser doesn't support javascript.
loading
RELATIONS BETWEEN ASTHMA AND OBESITY: AN ANALYSIS OF MULTIPLE FACTORS.
Madeira, Leticia Nabuco de Oliveira; Bordallo, Maria Alice Neves; Borges, Marcos Antonio; Lopes, Agnaldo José; Madeira, Isabel Rey; Kuschnir, Fábio Chigres.
Afiliação
  • Madeira LNO; Universidade Estadual do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Bordallo MAN; Universidade Estadual do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Borges MA; Universidade Estadual do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Lopes AJ; Universidade Estadual do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Madeira IR; Universidade Estadual do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Kuschnir FC; Universidade Estadual do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Rev Paul Pediatr ; 39: e2019405, 2020.
Article em En, Pt | MEDLINE | ID: mdl-33175004
OBJECTIVE: Asthma and obesity are prevalent and interrelated diseases. In the pediatric population, the effect of systemic inflammation associated to obesity, leading to inflammation of the airways, is currently controversial. Our aim was to compare inflammatory, clinical and spirometric patterns between children with asthma and obesity and those within the normal weight status range. METHODS: A total of 79 boys and girls from 6 to 10 years old were selected and divided into four groups: obese asthmatics, non-obese asthmatics, obese non-asthmatics, and non-obese non-asthmatics. In addition to collecting clinical and anthropometric data, all children underwent spirometry and skin prick tests for inhalant allergens. Blood samples for measurement of cytokines and adipokines were also collected. RESULTS: Obese asthmatics had significantly worse control of asthma than non-obese asthmatics (OR 4.9; 95%CI 1.1‒22.1), regardless of sex, physical activity and atopy. No differences in spirometry, Th1 and Th2 cytokines and adipokines levels were observed among the four groups. The prick tests were positive in 81.8 and 80% of non-obese asthmatics and obese asthmatics, respectively. CONCLUSIONS: The degree of control of asthma was significantly lower in the obese group, regardless of the findings of no differences in spirometry. Extra-pulmonary factors could be responsible for this symptomatic profile. High positivity of skin test in both groups, which is considered a good marker of atopy, shows a preponderant atopic component in the genesis of asthma, both in children with obesity and in those within the normal weight status.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Espirometria / Obesidade Infantil Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Child / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En / Pt Revista: Rev Paul Pediatr Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Espirometria / Obesidade Infantil Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Child / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En / Pt Revista: Rev Paul Pediatr Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil