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Hypoadiponectinemia as a marker of increased cardiovascular risk in patients with non-alcoholic fatty liver disease: correlation with albumin/creatinine ratio.
Assem, Maha; Amin, Mona; Khalafallah, Osama; Hussien, Ahmed; Saif, Aasem; Mousa, Shrook.
Afiliação
  • Assem M; Internal Medicine Department, Cairo University, Cairo, Egypt.
  • Amin M; Internal Medicine Department, Cairo University, Cairo, Egypt.
  • Khalafallah O; Clinical and Chemical Pathology Department, Cairo University, Cairo, Egypt.
  • Hussien A; Internal Medicine Department, Cairo University, Cairo, Egypt.
  • Saif A; Internal Medicine Department, Cairo University, Cairo, Egypt, aasemsaif@yahoo.com; aasem.saif@kasralainy.edu.eg.
  • Mousa S; Internal Medicine Department, Cairo University, Cairo, Egypt.
Arch Endocrinol Metab ; 65(1): 93-97, 2021 Nov 01.
Article em En | MEDLINE | ID: mdl-33166436
OBJECTIVE: We assessed plasma adiponectin and its correlation with carotid intima-media-thickness (CIMT), as a marker of atherosclerosis, and urine albumin/creatinine ratio (ACR) in patients with non-alcoholic fatty liver disease (NAFLD). METHODS: The study included 100 Egyptian subjects (50 patients with NAFLD with no history of diabetes or hypertension and 50 age and sex-matched normal healthy control subjects). Urine albumin/creatinine ratio (ACR) was assessed in all participants and fasting plasma adiponectin was measured using ELISA technique. Ultrasonography was used to diagnose NAFLD. CIMT was assessed using high-resolution Doppler ultrasonography. RESULTS: Mild albuminuria was detected in patients with NAFLD (mean urine ACR = 42 ± 30 mg/g). Plasma adiponectin was significantly lower and urine ACR and CIMT significantly higher in patients with NAFLD as compared with the control group (P < 0.001 for all). A significant negative correlation was found between plasma adiponectin and both urine ACR and CIMT in patients with NAFLD (P < 0.001 and < 0.05 respectively). A significant positive correlation was also found between CIMT and urine ACR in those patients (P < 0.05). Plasma adiponectin and urine ACR were independent determinants of CIMT in patients with NAFLD (P < 0.01 and < 0.05 respectively). CONCLUSION: Patients with NAFLD, without diabetes, have an increased risk of atherosclerosis and cardiovascular disease. Hypoadiponectinemia and low-grade albuminuria are important markers of that risk.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Adiponectina / Hepatopatia Gordurosa não Alcoólica / Erros Inatos do Metabolismo Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Arch Endocrinol Metab Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Egito País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Adiponectina / Hepatopatia Gordurosa não Alcoólica / Erros Inatos do Metabolismo Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Arch Endocrinol Metab Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Egito País de publicação: Brasil