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Neuromyelitis optica spectrum disorder: Do patients positive and negative for anti-aquaporin-4 antibodies present distinct entities? A Colombian perspective. / Espectro de neuromielitis óptica: ¿seropositivo para la anticuaporina es una entidad diferente de los pacientes que son seronegativos? Una perspectiva de Colombia.
Ortiz Salas, P A; Gaviria Carrillo, M; Cortés Bernal, G A; Moreno Medina, K; Roa, L F; Rodríguez Quintana, J H.
Afiliação
  • Ortiz Salas PA; Servicio de Neurología, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia; Universidad del Rosario, Grupo Neuros, Bogotá, Colombia. Electronic address: portizs@cardioinfantil.org.
  • Gaviria Carrillo M; Servicio de Neurología, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia; Universidad del Rosario. Programa de Neurología, Bogotá, Colombia.
  • Cortés Bernal GA; Universidad del Rosario. Programa de Neurología, Bogotá, Colombia.
  • Moreno Medina K; Departamento de Investigaciones, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia.
  • Roa LF; Hospital Universitario Mayor, Mederi, Bogotá, Colombia.
  • Rodríguez Quintana JH; Servicio de Neurología, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia; Universidad del Rosario, Grupo Neuros, Bogotá, Colombia; Hospital Universitario Mayor, Mederi, Bogotá, Colombia.
Neurologia (Engl Ed) ; 2020 Nov 05.
Article em En, Es | MEDLINE | ID: mdl-33162220
INTRODUCTION: Neuromyelitis optica (NMO) is an inflammatory disease of the central nervous system characterised by attacks of optic neuritis and longitudinally extensive transverse myelitis. The discovery of anti-aquaporin-4 (anti-AQP4) antibodies and specific brain MRI findings as diagnostic biomarkers have enabled the recognition of a broader and more detailed clinical phenotype, known as neuromyelitis optica spectrum disorder (NMOSD). OBJECTIVE: This study aimed to determine the demographic and clinical characteristics of patients with NMO/NMOSD with and without seropositivity for anti-AQP4 antibodies, in 2 quaternary-level hospitals in Bogotá. METHODS: Our study included patients > 18 years of age and diagnosed with NMO/NMOSD and for whom imaging and serology results were available, assessed between 2013 and 2017 at the neurology departments of hospitals providing highly complex care. Demographic, clinical, and imaging data were gathered and compared in patients with and without seropositivity for anti-AQP4 antibodies. RESULTS: The sample included 35 patients with NMO/NMOSD; the median age of onset was 46.5 years (P25-P75, 34.2-54.0); most patients had sensory (n = 25) and motor manifestations (n = 26), and a concomitant autoimmune disease was identified in 6. Twenty patients were seropositive for anti-AQP4 antibodies. Only age and presence of optic nerve involvement showed statistically significant differences between groups (p = .03). CONCLUSIONS: Clinical, imaging, and laboratory variables showed no major differences between patients with and without anti-AQP4 antibodies, with the exception of age of onset and presence of optic nerve involvement (uni- or bilateral); these factors should be studied in greater detail in larger populations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies País/Região como assunto: America do sul / Colombia Idioma: En / Es Revista: Neurologia (Engl Ed) Ano de publicação: 2020 Tipo de documento: Article País de publicação: Espanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies País/Região como assunto: America do sul / Colombia Idioma: En / Es Revista: Neurologia (Engl Ed) Ano de publicação: 2020 Tipo de documento: Article País de publicação: Espanha