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Aqueous chlorination of herbicide metribuzin: Identification and elucidation of "new" disinfection by-products, degradation pathway and toxicity evaluation.
de Barros, André Luis Corrêa; da Silva Rodrigues, Daniel Aparecido; da Cunha, Camila Cristina Rodrigues Ferreira; Chagas, Igor Aparecido Santana das; Santo, Daiana Rocha do Espirito; Silva, Silvana de Queiroz; Afonso, Robson José de Cássia Franco.
Afiliação
  • de Barros ALC; Postgraduation Program in Environmental Engineering (ProAmb), Universidade Federal de Ouro Preto (UFOP), Ouro Preto, MG, 35400-000, Brazil.
  • da Silva Rodrigues DA; Multicenter Postgraduation Program in Chemistry - Minas Gerais, Universidade Federal de Ouro Preto (UFOP), Ouro Preto, MG, 35400-000, Brazil.
  • da Cunha CCRF; Multicenter Postgraduation Program in Chemistry - Minas Gerais, Universidade Federal de Ouro Preto (UFOP), Ouro Preto, MG, 35400-000, Brazil.
  • Chagas IASD; Department of Biological Sciences, Universidade Federal de Ouro Preto (UFOP), Ouro Preto, MG, 35400-000, Brazil.
  • Santo DRDE; Department of chemistry, Universidade Federal de Ouro Preto (UFOP), Ouro Preto, MG, 35400-000, Brazil.
  • Silva SQ; Postgraduation Program in Environmental Engineering (ProAmb), Universidade Federal de Ouro Preto (UFOP), Ouro Preto, MG, 35400-000, Brazil; Department of Biological Sciences, Universidade Federal de Ouro Preto (UFOP), Ouro Preto, MG, 35400-000, Brazil.
  • Afonso RJCF; Postgraduation Program in Environmental Engineering (ProAmb), Universidade Federal de Ouro Preto (UFOP), Ouro Preto, MG, 35400-000, Brazil; Multicenter Postgraduation Program in Chemistry - Minas Gerais, Universidade Federal de Ouro Preto (UFOP), Ouro Preto, MG, 35400-000, Brazil; Department of chem
Water Res ; 189: 116545, 2021 Feb 01.
Article em En | MEDLINE | ID: mdl-33160237
A widely used herbicide, metribuzin, was evaluated for degradation, mineralization and disinfection by-products (DBPs) formation during aqueous chlorination. In addition, to assess the toxicity effects of chlorination on metribuzin solution the following tests were performed: acute toxicity using Artemia salina nauplii; cell viability using MTT assay; estrogenicity using a re-engineered Bioluminescent Yeast Estrogen Screen (BLYES) and a constitutively bioluminescent strain (BLYR); mutagenicity and developmental toxicity using Q(SAR) methodology. Metribuzin at 10 mg·L-1 was degraded by chlorination, achieving 93% of removal at 30 min of reaction. TOC analysis showed that the herbicide does not suffer complete mineralization, even after 24 h of contact with free chlorine. Seventeen DBPs were detected and their structural formulae were elucidated by high resolution mass spectrometry. Toxicity effects for chlorinated solutions increased when compared to the unreacted metribuzin solution. DBPs were more toxic to Artemia salina nauplii, increasing around 20% on nauplii mortality. It was also observed high estrogenicity to human receptors in BLYES assays and mutagenic and developmental toxicant effects to animals and humans in Q(SAR) methodology, suggesting that DBPs are potentially more toxic than the precursor metribuzin. Metribuzin solutions at 10 mg·L-1 showed equivalent 17-ß-estradiol values ranged from 0.061 to 6.71 µg·L-1 after to be chlorinated at different reaction times.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poluentes Químicos da Água / Purificação da Água / Desinfetantes / Herbicidas Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: Water Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poluentes Químicos da Água / Purificação da Água / Desinfetantes / Herbicidas Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: Water Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido