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Influence of Single Nucleotide Polymorphisms of ELOVL on Biomarkers of Metabolic Alterations in the Mexican Population.
Maycotte-Cervantes, María Luisa; Aguilar-Galarza, Adriana; Anaya-Loyola, Miriam Aracely; Anzures-Cortes, Ma de Lourdes; Haddad-Talancón, Lorenza; Méndez-Rangel, Akram Sharim; García-Gasca, Teresa; Rodríguez-García, Víctor Manuel; Moreno-Celis, Ulisses.
Afiliação
  • Maycotte-Cervantes ML; Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Juriquilla, Querétaro CP 76230, Mexico.
  • Aguilar-Galarza A; Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Juriquilla, Querétaro CP 76230, Mexico.
  • Anaya-Loyola MA; Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Juriquilla, Querétaro CP 76230, Mexico.
  • Anzures-Cortes ML; Código 46 SA de CV, Cuernavaca, Morelos 62498, Mexico.
  • Haddad-Talancón L; Código 46 SA de CV, Cuernavaca, Morelos 62498, Mexico.
  • Méndez-Rangel AS; Código 46 SA de CV, Cuernavaca, Morelos 62498, Mexico.
  • García-Gasca T; Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Juriquilla, Querétaro CP 76230, Mexico.
  • Rodríguez-García VM; Tecnológico de Monterrey, Escuela de Ingeniería y Ciencias, San Pablo, Querétaro 76130, Mexico.
  • Moreno-Celis U; Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Juriquilla, Querétaro CP 76230, Mexico.
Nutrients ; 12(11)2020 Nov 04.
Article em En | MEDLINE | ID: mdl-33158152
The elongation of very long chain fatty acids (ELOVL) is a family of seven enzymes that have specific functions in the synthesis of fatty acids. Some have been shown to be related to insulin secretion (ELOVL2), and in the lipid profile (ELOVL6) and patients with various pathologies. The present work focused on the study of ELOVL polymorphs with clinical markers of non-communicable chronic diseases in the Mexican population. A sample of 1075 participants was obtained, who underwent clinical, biochemical, and nutritional evaluation, and a genetic evaluation of 91 genetic variants of ELOVL was considered (2-7). The results indicate a 33.16% prevalence of obesity by body mass index, 13.84% prevalence of insulin resistance by homeostatic model assessment (HOMA) index, 7.85% prevalence of high cholesterol, and 20.37% prevalence of hypercholesterolemia. The deprived alleles showed that there is no association between them and clinical disease risk markers, and the notable finding of the association studies is that the ELOVL2 variants are exclusive in men and ELVOL7 in women. There is also a strong association of ELOVL6 with various markers. The present study shows, for the first time, the association between the different ELOVLs and clinical markers of chronic non-communicable diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores / Polimorfismo de Nucleotídeo Único / Elongases de Ácidos Graxos / Metabolismo Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male País/Região como assunto: Mexico Idioma: En Revista: Nutrients Ano de publicação: 2020 Tipo de documento: Article País de afiliação: México País de publicação: Suíça
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores / Polimorfismo de Nucleotídeo Único / Elongases de Ácidos Graxos / Metabolismo Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male País/Região como assunto: Mexico Idioma: En Revista: Nutrients Ano de publicação: 2020 Tipo de documento: Article País de afiliação: México País de publicação: Suíça